High amplitude high frequency oscillations during posttraumatic epileptogenesis  

作　　者：Jagannathan Rangarajan Udaya Kumar 

机构地区：[1]Department of Neurology,University of California Los Angeles,Los Angeles 90024,California,U.S.A.

出　　处：《Brain Science Advances》2023年第4期275-282,共8页神经科学（英文）

基　　金：supported by research grants from the National Institutes of Health,USA。

摘　　要：Background: The aim of the present study was to investigate if high amplitude high frequency oscillations(haHFOs) could be a biomarker of posttraumatic epileptogenesis. Methods: After an initial craniotomy of rats and inducement of traumatic brain injury(TBI) through a fluid percussion, recording microelectrodes were implanted bilaterally in different brain areas.Wideband brain electrical activity was recorded intermittently from Day 1 of TBI and continued till week 21. HaHFO analysis was performed during the first 4 weeks to investigate whether the occurrence of this brain activity predicted development of epilepsy or not. Results: Of the 21 rats which received the TBI, 9 became epileptic(E+) and 12 did not(E-). HaH FOs were observed in the prefrontal and perilesional cortices, hippocampus, and striatum in both E+ and E-group. In comparison to the rats in E-, the E+ group showed a significant increase in the rate of haHFO from weeks 1 to 4 after TBI.Conclusion: The results indicate that an increase in the rate of haHFOs after TBI could be an electroencephalographic biomarker of posttraumatic epileptogenesis.

关 键 词：traumatic brain injury EPILEPSY high frequency oscillations BIOMARKER 

分 类 号：R742.1[医药卫生—神经病学与精神病学]