癌症中核糖体RNA上的修饰:生物学功能和治疗靶点  

Ribosome RNA modification in cancer:Biological functions and therapeutic targets

作　　者：杨先远 陶丽君 周嘉旺 张坤 王红胜 Xianyuan Yang;Lijun Tao;Jiawang Zhou;Kun Zhang;Hongsheng Wang(Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China;The Second Affiliated Hospital of Chengdu Medical College,China National Nuclear Corporation 416 Hospital,Chengdu Seventh People’s Hospital,Affiliated Cancer Hospital of Chengdu Medical College,School of Biological Sciences and Technology,Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China [2]The Second Affiliated Hospital of Chengdu Medical College,China National Nuclear Corporation 416 Hospital,Chengdu Seventh People’s Hospital,Affiliated Cancer Hospital of Chengdu Medical College,School of Biological Sciences and Technology,Chengdu Medical College,Chengdu 610500,China

出　　处：《Science Bulletin》2024年第6期722-726,共5页科学通报（英文版）

基　　金：supported by the National Key Research and Development Program of China(2022YFC2601800);the Key-Area Research and Development Program of Guangdong Province(2023B1111020007);the National Natural Science Foundation of China(32161143017,82173833,81973343,and 82272658);the Guangdong Basic and Applied Basic Research Foundation(2023B1515040006);the Open Program of Shenzhen Bay Laboratory(SZBL202009051006);the Guangdong Provincial Key Laboratory of Construction Foundation(2023B1212060022);the Sichuan Science and Technology Program(2022JDRC0042 and 2022NSFSC0776);the Joint Research Foundation of Chengdu Medical College and the Seventh People’s Hospital(2022LHTD-02,2021LHJYPJ-08,and 2022488);the Shenzhen Bay Scholars Program。

摘　　要：The ribosome is a cellular system responsible for translating the nucleotide code of mRNA into proteins.In human cells,this complex consists of four distinct ribosomal RNAs(rRNAs):The 28S,18S,5.8S,and 5S rRNAs,along with 80 ribosomal proteins.Polymerase Ⅰ is responsible for synthesizing the 28S,18S,and 5.8S rRNAs,while polymerase Ⅲ is responsible for synthesizing the 5S rRNA[1].

关 键 词：核糖体RNA 治疗靶点 RRNA 18S 

分 类 号：R730.2[医药卫生—肿瘤]