功能性甜味剂对肥胖的作用及相关机制  

Effect and Mechanism of Functional Sweetener on Obesity:A Review

作　　者：甘利平 赵宜丰 洪图 周泳琪 赵鑫 黄伟豪 史柳莹 李怡磊 GAN Liping;ZHAO Yifeng;HONG Tu;ZHOU Yongqi;ZHAO Xin;HUANG Weihao;SHI Liuying;LI Yilei(College of Biological Engineering,Henan University of Technology,Zhengzhou 450001,China)

机构地区：[1]河南工业大学生物工程学院,河南郑州450001

出　　处：《食品科学》2024年第9期252-260,共9页Food Science

基　　金：国家自然科学基金青年科学基金项目(32202696);“十四五”国家重点研发计划重点专项(2022YFD1300604);河南工业大学高层次人才科研启动基金项目(31401405);河南工业大学青年骨干教师培育计划项目(21421255)。

摘　　要：肥胖已经成为威胁人类健康的一个严重问题,其中糖类摄入过多是造成肥胖的主要原因之一。因此,使用低热量的功能性甜味剂代替高热量的糖类(例如蔗糖)是目前广受欢迎的一种预防或缓解肥胖的方式。然而,功能性甜味剂与肥胖之间的关系十分复杂,目前尚无定论。这是由于功能性甜味剂的作用受多种因素的影响,包括功能性甜味剂的种类、剂量,以及个体差异,例如性别、健康状态和肠道微生物的组成等。本文综述目前常用的功能性甜味剂对机体能量代谢的影响、对脂肪代谢的影响以及对肠道微生物的作用,总结目前功能性甜味剂对肥胖作用的相关研究,并探讨功能性甜味剂影响肥胖的可能机制,以期为今后更好地选择或使用含有功能性甜味剂的食物和饮品提供参考。Obesity has become a serious threat to human health,with excessive intake of sugar being one of the major causes of obesity.Therefore,replacing high-calorie sugar with low-calorie functional sweeteners or sugar substituents is a popular dietary choice for the prevention and management of obesity.However,the relationship between functional sweeteners and obesity is complex,and no definitive conclusion has been reached.This is because the effect of functional sweeteners is influenced by various factors,including the type and dosage of functional sweetener,as well as individual differences such as gender,health status and gut microbiota composition.In this article,we review the effect of common functional sweeteners on energy metabolism,fat metabolism and the gut microbiota in the body.Furthermore,we summarize the current studies on the effect and mechanism of functional sweeteners on obesity hoping to provide a reference for better selection or application of foods and beverages containing non-nutritional sweeteners in the future.

关 键 词：功能性甜味剂 肥胖 能量代谢 肠道微生物 机制 

分 类 号：TS202.3[轻工技术与工程—食品科学]