An overview of potential cardioprotective benefits of xanthophylls in atherosclerosis:an evidence-based review  

作　　者：Yuting Su Feng Chen Jiehua Chen Mingfu Wang 

机构地区：[1]Shenzhen Key Laboratory of Marine Microbiome Engineering,Institute for Advanced Study,Shenzhen University,Shenzhen 518060,China [2]Institution for Innovative Development of Food Industry,Shenzhen University,Shenzhen 518060,China [3]College of Civil and Transportation Engineering,Shenzhen University,Shenzhen 518060,China [4]Shenzhen Key Laboratory of Food Nutrition and Health,Shenzhen University,Shenzhen 518060,China

出　　处：《Food Science and Human Wellness》2024年第4期1739-1755,共17页食品科学与人类健康（英文）

基　　金：supported by the National Key R&D Program of China(YFD2100103).

摘　　要：Atherosclerosis,as the most prevalent form of cardiovascular disease,is characterized by oxidized lowdensity lipoprotein(ox-LDL)accumulation in the vascular wall,increased inflammation of the large arteries,dysfunction of the endothelial cells(ECs)and vascular smooth muscle cells(VSMCs),which may eventually lead to the formation of plaques.Xanthophylls,one of the main groups of carotenoids,have been proposed as preventive agents or adjunct therapies to prevent and slow the progression of atherosclerosis due to their cardioprotective properties.However,the underlying preventive mechanism of action of xanthophylls on the pathogenesis of atherosclerosis remains unclear,and clinical evidence of the effect of xanthophylls on atherosclerosis have not yet been summarized and critically reviewed.In this regard,we conducted a comprehensive literature search in four scientific databases(Pub Med,Google Scholar,Science Direct and Web of Science)and carefully analyzed the existing evidence to provide meaningful insights on the association between xanthophylls and atherosclerosis from various aspects.Based on the evidence from in vitro and in vivo studies,we explored several potential mechanisms,including antioxidant effect,anti-inflammatory effect,regulation of lipid metabolism,and modulation of ECs and VSMCs dysfunction,and we found that a clear picture of regulatory pathways of xanthophylls on atherosclerosis prevention and treatment is still lacking.In addition,epidemiological studies suggested the possible relationship among high dietary intake of xanthophylls,high plasma/serum xanthophylls and a reduced risk of atherosclerosis.Direct evidence from interventional studies investigating the effect of xanthophylls on atherosclerosis is very sparse,whilst indirect clinical evidence was only limited to astaxanthin and lutein.Therefore,well-designed long-term randomized controlled trials(RCTs)are highly recommended for future studies to investigate the effective dose of different xanthophylls on atherosclerosis prevention and t

关 键 词：ATHEROSCLEROSIS XANTHOPHYLLS ANTIOXIDANT ANTI-INFLAMMATION Lipid metabolism 

分 类 号：TS201.4[轻工技术与工程—食品科学] R543.5[轻工技术与工程—食品科学与工程]