The role and applications of extracellular vesicles in osteoporosis  

作　　者：Fei Fang Jie Yang Jiahe Wang Tiantian Li Erxiang Wang Demao Zhang Xiaoheng Liu Chenchen Zhou 

机构地区：[1]Institute of Biomedical Engineering,West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,Chengdu 610041,China [2]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China

出　　处：《Bone Research》2024年第1期62-77,共16页骨研究（英文版）

基　　金：This study was supported by the National Natural Science Foundation of China(Grant numbers 11932014,12372315 and 32301089);the Sichuan Science and Technology Program(Grant numbers 2022NSFSC0765 and 2022ZYD0079).

摘　　要：Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture,which increases patient susceptibility to fragile fractures.The intricate mechanisms governing bone homeostasis are substantially impacted by extracellular vesicles(EVs),which play crucial roles in both pathological and physiological contexts.EVs derived from various sources exert distinct effects on osteoporosis.Specifically,EVs released by osteoblasts,endothelial cells,myocytes,and mesenchymal stem cells contribute to bone formation due to their unique cargo of proteins,miRNAs,and cytokines.Conversely,EVs secreted by osteoclasts and immune cells promote bone resorption and inhibit bone formation.Furthermore,the use of EVs as therapeutic modalities or biomaterials for diagnosing and managing osteoporosis is promising.Here,we review the current understanding of the impact of EVs on bone homeostasis,including the classification and biogenesis of EVs and the intricate regulatory mechanisms of EVs in osteoporosis.Furthermore,we present an overview of the latest research progress on diagnosing and treating osteoporosis by using EVs.Finally,we discuss the challenges and prospects of translational research on the use of EVs in osteoporosis.

关 键 词：OSTEOPOROSIS HOMEOSTASIS BIOMATERIALS 

分 类 号：R580[医药卫生—内分泌]