MMR、PD-L1在子宫内膜样癌中的表达及其与预后的相关性  

The expression of MMR,PD-L1 in endometrioid adenocarcinoma and their correlation with prognosis

作　　者：张维新 孙慧敏 高建芳 张梦雪 柳林[2] ZHANG Weixin;SUN Huimin;GAO Jianfang;ZHANG Mengxue;LIU Lin(Weifang Medical University,Weifang 261041,Shandong,China;Department of Gynecology,Weifang People′s Hospital,Weifang 261041,Shandong,China)

机构地区：[1]潍坊医学院,山东潍坊261041 [2]潍坊市人民医院妇科,山东潍坊261041

出　　处：《西部医学》2024年第5期691-696,701,共7页Medical Journal of West China

基　　金：潍坊市软科学研究计划(2021RKX009)。

摘　　要：目的探讨错配修复蛋白(MMR)、程序性死亡配体-1(PD-L1)在子宫内膜样癌(EEC)中的表达及其与预后的关系。方法收集2015年1月-2020年9月潍坊市人民医院病理科诊断的EEC组织标本90例、子宫内膜不典型增生组织30例、子宫内膜样癌旁组织30例及子宫内膜不典型增生旁组织10例,对不同子宫内膜组织中的MMR、PD-L1表达情况采用免疫组化法进行检测,分析MMR、PD-L1表达与患者临床病理特征关系及与预后的相关性。结果MMR缺失(dMMR)、PD-L1在EEC组织中表达高于不典型增生组织、子宫内膜不典型增生旁组织及EEC旁组织(检验水准<0.017);dMMR、PD-L1与EEC的年龄及淋巴结转移、FIGO分期、肌层浸润深度无关(P>0.05);PD-L1的表达在G3期较G1期表达上调(检验水准<0.017);PD-L1与dMMR呈正相关(P<0.05);dMMR、PD-L1与患者预后有关,dMMR、PD-L1阳性的患者预后更差,MMR可以作为影响EEC患者生存的独立因素(P<0.05)。结论dMMR、PD-L1在EEC发生发展过程中起协同作用。dMMR、PD-L1与患者预后有关。dMMR是影响EEC预后的独立因素,联合检测MMR、PD-L1可能为EEC预后评估提供理论依据。Objective To investigate the expression of mismatch repair protein(MMR)and programmed death ligand 1(PD-L1)in endometrioid adenocarcinoma(EEC)and their relationship with prognosis.Methods From January 2015 to September 2020,90 endometrioid adenocarcinoma tissues,30 endometrium atypical hyperplasia tissues,10 atypical accessory tissue and 30 paracancerous tissues were collected from Department of Pathology of Weifang People's Hospital of Shandong Province.The expression of MMR,PD-L1 was detected by immunohistochemistry.And Analyzed MMR,PD-L1 and the patient clinical pathology characteristic relevance and prognosiswere analyzed.Results MMR deletions(deficient MMR,dMMR),PD-L1 were higher in EEC tissues than in atypical hyperplasia tissues and control groups(Inspection level<0.017).dMMR,PD-L1 were not related to FIGO staging,age,lymph node metastasis,and muscle infiltration depth of EEC patient(P>0.05).The expression of PD-L1 was upregulated in the G3 phase compared with the G1 phase(Inspection level<0.017).PD-L1 was positively correlated with dMMR(P<0.05).dMMR,PD-L1 were related to patient prognosis,of which dMMR,PD-L1 positive patients had a worse prognosis.MMR could be used as an independent factor affecting the survival of EEC patients(P<0.05).Conclusion dMMR,PD-L1 play a synergistic role in the occurrence and development of EEC.Absence of MMR and PD-L1 are related to prognosis of patients.dMMR is an independent factor affecting the prognosis of EEC,and the combined detection of MMR and PD-L1 may provide a theoretical basis for the prognosis assessment of EEC.

关 键 词：子宫内膜样癌 MMR PD-L1 临床预后 

分 类 号：R737.33[医药卫生—肿瘤]