Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior  

作　　者：Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng 

机构地区：[1]Brain Science and Advanced Technology Institute,Wuhan University of Science and Technology,Wuhan,Hubei Province,China [2]Geriatric Hospital Affiliated to Wuhan University of Science and Technology,Wuhan,Hubei Province,China [3]School of Public Health,Wuhan University of Science and Technology,Wuhan,Hubei Province,China

出　　处：《Neural Regeneration Research》2025年第1期159-173,共15页中国神经再生研究（英文版）

基　　金：supported financially by the National Natural Science Foundation of China,No.82071272(to YZ).

摘　　要：Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and hippocampus.Determining how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress psychopathology.In this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of depression.We focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine circuit.We determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic system.Therefore,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关 键 词：AMYGDALA chronic mild stress chronic social defeat stress corticolimbic system DEPRESSION HIPPOCAMPUS medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area 

分 类 号：R749.4[医药卫生—神经病学与精神病学]