Fibrinogen’s potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer’s disease  

作　　者：Vishal Singh Arnab Choudhury Hyung Jin Ahn 

机构地区：[1]Department of Pharmacology,Physiology and Neurosciences,Rutgers-New Jersey Medical School,Newark,NJ,USA [2]Brain Health Institute,Rutgers University,Piscataway,NJ,USA

出　　处：《Neural Regeneration Research》2025年第1期203-204,共2页中国神经再生研究（英文版）

基　　金：supported by the National Institute of Health NS104386(to HJA)and AG078245(to HJA).

摘　　要：Alzheimer’s disease(AD)stands out as the primary manifestation of age-related dementia,portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ)plaques and neurofibrillary tangles of hyperphosphorylated tau.However,from a clinical standpoint,AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological mechanism.An often-overlooked aspect of the disease is the presence of extensive cerebrovascular abnormalities,given that the majority of AD patients experience altered cerebral blood flow,damaged vasculature,increased microinfarcts and microhemorrhages.Animal models of AD further support this observation,showing cerebrovascular dysfunction such as impaired cerebral blood flow and altered cerebrovascular reactivity(Tataryn et al.,2021;Gareau et al.,2023).

关 键 词：CEREBROVASCULAR DYSFUNCTION ALZHEIMER 

分 类 号：R749.16[医药卫生—神经病学与精神病学]