Interleukin 1βreceptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1  

作　　者：Roberto Piacentini Claudio Grassi 

机构地区：[1]Department of Neuroscience,UniversitàCattolica del Sacro Cuore,Rome,Italy [2]Fondazione Policlinico Universitario A.Gemelli,IRCCS,Rome,Italy

出　　处：《Neural Regeneration Research》2025年第2期416-423,共8页中国神经再生研究（英文版）

基　　金：supported by UniversitàCattolica(D1 intramural funds to RP);Italian Ministry of University and Research(PRIN 2022ZYLB7B,P2022YW7BP funds to CG).

摘　　要：Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s disease.However,the molecular mechanisms underlying this association are not completely understood.Among the molecular mediators of synaptic and cognitive dysfunction occurring after Herpes simplex virus type-1 infection and reactivation in the brain neuroinflammatory cytokines seem to occupy a central role.Here,we specifically reviewed literature reports dealing with the impact of neuroinflammation on synaptic dysfunction observed after recurrent Herpes simplex virus type-1 reactivation in the brain,highlighting the role of interleukins and,in particular,interleukin 1βas a possible target against Herpes simplex virus type-1-induced neuronal dysfunctions.

关 键 词：herpes simplex virus type 1 interleukin 1β MICROGLIA NEUROINFLAMMATION synaptic dysfunction 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R512.3[医药卫生—临床医学]