Skull and vertebral bone marrow in central nervous system inflammation  

作　　者：Honglei Ren Qiang Liu 

机构地区：[1]Department of Neurology,Tianjin Neurological Institute,Tianjin Institute of Immunology,State Key Laboratory of Experimental Hematology,International Joint Laboratory of Ocular Diseases,Ministry of Education,Haihe Laboratory of Cell Ecosystem,Tianjin Medical University General Hospital,Tianjin 300052,China

出　　处：《Fundamental Research》2024年第2期246-250,共5页自然科学基础研究（英文版）

基　　金：supported in part by the National Natural Science Foundation of China(82225015,82171284,and 82201498).

摘　　要：Emerging evidence has highlighted the capacity of hematogenous cells in skull and vertebral bone marrow to enter the meningeal borders via ossified vascular channels and maintain immune homeostasis in the central nervous system(CNS).CNS-adjacent skull and vertebral bone marrow comprises hematopoietic niches that can sense CNS injury and supply specialized immune cells to fine-tune inflammatory responses.Here,we review recent advances in our understanding of skull and vertebral bone marrow-derived immune cells in homeostasis and inflammatory CNS diseases.Further,we discuss the implications for future development of therapies to mitigate CNS inflammation and its detrimental sequelae in neurological disorders.

关 键 词：Central nervous system Bone marrow HEMATOPOIESIS Immune cells NEUROINFLAMMATION Stroke Multiple sclerosis 

分 类 号：R741[医药卫生—神经病学与精神病学]