Gut microbiota-astrocyte axis: new insights into age-related cognitive decline  

作　　者：Lan Zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei 

机构地区：[1]Haihe Laboratory of Cell Ecosystem,Department of Geriatrics,Tianjin Medical University General Hospital,Tianjin,China [2]Tianjin Geriatrics Institute,Tianjin Medical University General Hospital,Tianjin,China [3]Department of Gastroenterology and Hepatology,Tianjin Medical University General Hospital,National Key Clinical Specialty,Tianjin Institute of Digestive Diseases,Tianjin Key Laboratory of Digestive Diseases,Tianjin,China [4]Department of Urology,Tianjin Medical University General Hospital,Tianjin,China [5]Tianjin Neurological Institution,Tianjin Medical University General Hospital,Tianjin,China

出　　处：《Neural Regeneration Research》2025年第4期990-1008,共19页中国神经再生研究（英文版）

基　　金：supported by the Haihe Laboratory of Cell Ecosystem Innovation Foundation,No.22HHXBSS00047(to PL);Graduate Science and Technology Innovation Project of Tianjin,No.2022BKY173(to LZ);Tianjin Municipal Science and Technology Bureau Foundation,No.20201194(to PL).

摘　　要：With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of astrocytes.The microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive function.This article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative diseases.This article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial metabolites.Finally,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s diseases.Our findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关 键 词：age aging Alzheimer’s disease ASTROCYTES cognitive decline dementia gut microbiota gut–brain axis microbial metabolites NEUROINFLAMMATION Parkinson’s disease 

分 类 号：R36[医药卫生—病理学]