Hypoxic tumor microenvironment:Destroyer of natural killer cell function  

作　　者：Yongfei Zhang Feifei Guo Yufeng Wang 

机构地区：[1]Cancer Center,the First Hospital of Jilin University,Changchun 130021,China

出　　处：《Chinese Journal of Cancer Research》2024年第2期138-150,共13页中国癌症研究（英文版）

摘　　要：In recent years, immunotherapy has made remarkable progress in treating certain tumors and hematological malignancies. However, the efficacy of natural killer(NK) cells, which are an important subset of innate lymphocytes used in anticancer immunotherapy, remains limited. Hypoxia, a critical characteristic of the tumor microenvironment(TME), is involved in tumor development and resistance to radiotherapy, chemotherapy, and immunotherapy. Moreover, hypoxia contributes to the impairment of NK cell function and may be a significant factor that limits their therapeutic effects. Targeted hypoxia therapy has emerged as a promising research area for enhancing the efficacy of NK cell therapy. Therefore, understanding how the hypoxic TME influences NK cell function is crucial for improving antitumor treatment outcomes.

关 键 词：HYPOXIA IMMUNOTHERAPY NK cell tumor microenvironment 

分 类 号：R730.51[医药卫生—肿瘤]