Let-7i-5p maintains the stemness via R-spondin2/Wnt pathway in hepatocellular carcinoma  

作　　者：Qinghua Wei Xueshan Dai Jiahui Wei Wenwei Sun Xiaoqian Yang Yuxin Zhang Xin Guo Yi Chen 

机构地区：[1]College of Pharmaceutical Sciences&Chinese Medicine,Southwest University,Chongqing 400716,China [2]Center for Basic Medical Research,TEDA International Cardiovascular Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300457,China [3]Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine,Chongqing 400716,China [4]pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine,Chongqing 400716,China [5]Division of Cell,Developmental and Integrative Biology,School of Medicine,South China University of Technology,Guangzhou,Guangdong 510006,China [6]National Demonstration Center for Experimental Pharmacy Education(Southwest University),Chongqing 400716,China [7]Engineering Research Center of Coptis Development and Utilization(Ministry of Education),College of Pharmaceutical Sciences and Chinese Medicine,Southwest University,Chongqing 400716,China

出　　处：《Genes & Diseases》2024年第4期20-23,共4页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.81773984,81402441);Chongqing Natural Science Foundation of China(No.CSTC2020JCYJMSXMX0451);Traditional Chinese medicine research project of Chongqing Health Bureau(No.2020ZY023665);Chinese Medicine Rehabilitation-the Key Discipline Constructed by Chongqing Health Bureau(No.2021-4322190044);Fundamental Research Funds for the Central Universities(China)(No.XDJK2012C054);Southwest University Doctor Foundation(Chongqing,China)(No.SWU111074).

摘　　要：Cancer stem cells(CSCs)are related to tumorigenesis,recurrence,metastasis,and drug resistance in hepatocellular carcinoma(HCC).1 Let-7i is a noncoding small RNA,belonging to the famous miRNA let-7 family.Recently,let-7i has been revealed as a tumor suppressor on CsCs in ovarian cancer.

关 键 词：HEPATOCELLULAR Cancer METASTASIS 

分 类 号：R735.7[医药卫生—肿瘤]