生物活性肽调控细胞凋亡作用机制的研究进展  

Research progress on the mechanism of bioactive peptides regulating cell apoptosis

作　　者：徐琳杰 蒋蓉 张成桂 隋世燕 XU Lin-Jie;JIANG Rong;ZHANG Cheng-Gui;SUI Shi-Yan(School of Public Health,Dali University,Dali 671000,China;Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical Research and Development,Dali 671000,China)

机构地区：[1]大理大学公共卫生学院,大理671000 [2]云南省昆虫生物医药研发重点实验室,大理671000

出　　处：《食品安全质量检测学报》2024年第9期240-249,共10页Journal of Food Safety and Quality

基　　金：国家自然科学基金项目(32260865、31760719);云南省科技厅科技特派团项目(202104BI090026);云南省科技厅基础研究计划项目(202101BA070001-202);云南省高层次科技人才及创新团队选拔专项(202305AC160037);云南省科技人才与平台(专家工作站)计划项目(202305AF150083);云南省昆虫生物医药重点实验室开放项目(AT2022001)。

摘　　要：生物活性肽相较于传统药物具有副作用小、安全性高的特点,逐渐在被人们接受,在治疗疾病和开发功能性食品的过程中极为重要。氧化应激对机体造成严重损害,如何清除氧化应激产生的活性氧是我们目前面临的重大难题,而生物活性肽能够抑制氧化应激诱导的细胞凋亡。本文对生物活性肽通过线粒体途径和死亡受体途径抑制正常细胞凋亡和促进癌细胞凋亡以及通过促进线粒体自噬来调控细胞凋亡的作用机制进行综述,以期充分了解生物活性肽的生理功能及其作用机制,为生物活性肽作用机制的深入研究及其开发利用提供参考依据。Compared to traditional drugs,bioactive peptides have the characteristics of small side effects and high safety,and are gradually being accepted by people.They are extremely important in the treatment of diseases and the development of functional foods.Oxidative stress causes serious damage to the body,and how to clear the reactive oxygen species produced by oxidative stress is a major challenge we are currently facing.Bioactive peptides can inhibit oxidative stress-induced apoptosis.This article reviewed the mechanisms by which bioactive peptides inhibited normal cell apoptosis and promoted cancer cell apoptosis through the mitochondrial and death receptor pathways,as well as regulated apoptosis through the promotion of mitochondrial autophagy.The aim is to fully understand the physiological functions and mechanisms of bioactive peptides,and provide reference for the depth research and development of bioactive peptide mechanisms.

关 键 词：生物活性肽 细胞凋亡 氧化应激 线粒体自噬 线粒体途径 死亡受体途径 

分 类 号：TS201.4[轻工技术与工程—食品科学]