双烯丙醇一锅法合成的有机化学综合实验教学设计  

Teaching Design on Comprehensive Experiment in Organic Chemistry of One-Pot Method Synthesis of Diallyl Alcohol

作　　者：刘长青 李慧娟 张恩立 袁明 薛洪宝 LIU Chang-qing;LI Hui-juan;ZHANG En-li;YUAN Ming;XUE Hong-bao(Bengbu Medical University,Department of Drug Synthesis,Bengbu,Anhui,233030)

机构地区：[1]蚌埠医科大学药物合成教研室,安徽蚌埠233030

出　　处：《贵州师范学院学报》2024年第6期68-75,共8页Journal of Guizhou Education University

基　　金：安徽省教学研究重点项目“新工科背景下基于OBE理念的《有机化学》教学探究与实践”(2022jyxm995);安徽省新时代育人质量工程研究生教育项目“安徽宏业药业硕士后工作站建设”(2022sshqygzz033);安徽省教学研究一般项目“药物分离纯化技术课程多样化教学模式探讨与改革模式探究”(2020jyxm1167)。

摘　　要：结合课题组的前期研究成果,介绍了一个格氏试剂、炔基砜和查尔酮的一锅法合成双烯丙醇的有机化学综合实验教学设计。产物结构经过^(1)H NMR、^(13)C NMR和HRMS表征,并通过自动熔点仪测定出产物的熔点。实验中涉及格氏试剂的制备以及化学性质的研究,丰富了有机化学实验的教学内容。将科研成果融入到有机化学综合实验教学中,不仅能够锻炼学生的综合实验技能和提高学习兴趣,而且能够拓宽学生的科学研究视角和激发学生的创新思维能力;同时,这也能为学生本科毕业论文设计的开展打下扎实的基础。Combining with the previous research achievements of the research group,this paper introduces the teaching design of an organic chemistry comprehensive experiment on the one-pot synthesis of diallyl alcohols using Grignard reagents,alkynyl sulfones,and chalcones.The structure of the product was characterized by^(1)H NMR,^(13)C NMR and HRMS,and the melting point of the product was determined by automatic melting point apparatus.This experiment involves the preparation of Grignard reagent and the study of chemical properties,which enriches the content of organic chemistry experiment teaching.Through the organic combination of scientific research results and organic chemistry experiment teaching,students'comprehensive experimental skills can be trained,their interest in experiments can be enhanced,their scientific research horizons can be broadened,and their innovation ability can be stimulated,which also lays a good foundation for the subsequent undergraduate graduation thesis.

关 键 词：教学设计 有机化学综合实验 格氏试剂 炔基砜 查尔酮 双烯丙醇 

分 类 号：G420[文化科学—课程与教学论]