Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy  

作　　者：Afsana Sheikh Prashant Kesharwani Waleed H.Almalki Salem Salman Almujri Linxin Dai Zhe‑Sheng Chen Amirhossein Sahebkar Fei Gao 

机构地区：[1]Department of Pharmaceutics,School of Pharmaceutical Education and Research,Jamia Hamdard,New Delhi 110062,India [2]Department of Pharmacology and Toxicology,Faculty of Pharmacy,Umm Al-Qura University,Makkah,Saudi Arabia [3]Department of Pharmacology,College of Pharmacy,King Khalid University,61421 Asir‑Abha,Saudi Arabia [4]State Key Laboratory of Southwestern Chinese Medicine Resources,Pharmacy School,Chengdu University of Traditional Chinese Medicine,Chengdu 611130,People’s Republic of China [5]Department of Pharmaceutical Sciences,College of Pharmacy and Health Sciences,St.John’s University,New York 11439,USA [6]Biotechnology Research Center,Pharmaceutical Technology Institute,Mashhad University of Medical Sciences,Mashhad,Iran [7]Applied Biomedical Research Center,Mashhad University of Medical Sciences,Mashhad,Iran

出　　处：《Nano-Micro Letters》2024年第9期501-556,共56页纳微快报（英文版）

基　　金：National Natural Science Foundation of China[82274366];The National Multidisciplinary Innovation Team Project of Traditional Chinese Medicine:Multi-dimensional Evaluation and Multidisciplinary Innovation Team of Southwest Traditional Chinese Medicine Resources[ZYYCXTD-D-202209];The Youth Talent Promotion Project of China Association of Chinese Medicine[2021-QNRC2-A09];The Major Project of Sichuan Provincial Administration of Traditional Chinese Medicine(2023ZD01);the financial support from the Indian Council of Medical Research(ICMR),New Delhi,India,through Extramural Research Grants.

摘　　要：As a new form of regulated cell death,ferroptosis has unraveled the unsolicited theory of intrinsic apoptosis resistance by cancer cells.The molecular mechanism of ferroptosis depends on the induction of oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage the structural integrity of cells.Due to their high loading and structural tunability,nanocarriers can escort the delivery of ferro-therapeutics to the desired site through enhanced permeation or retention effect or by active targeting.This review shed light on the necessity of iron in cancer cell growth and the fascinating features of ferroptosis in regulating the cell cycle and metastasis.Additionally,we discussed the effect of ferroptosis-mediated therapy using nanoplatforms and their chemical basis in overcoming the barriers to cancer therapy.

关 键 词：Ferroptosis NANOPARTICLES Ferrotherapy CANCER GENES NANOTECHNOLOGY TOXICITY Reactive oxygen species 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]