Ganoderma lucidum spore oil enhances the effect of paclitaxel,improves the tolerance to paclitaxel and prolongs the survival in Lewis tumor-bearing mice  

作　　者：Hong-Fei Cai Zhao-Jian Jiang Cheng Yuan Lin Cao Qin Wang Ya-Ming Han Qin Zhang Jing Li Wen-Dong Xu Ju-Yan Liu 

机构地区：[1]Guangzhou HanFang Pharmaceutical Company Limited,National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug Innovation,Guangdong Provincial Key Laboratory of Medicinal Lipids,Guangzhou 510240,China [2]Nanchang Research Institute,Sun Yat-Sen University,Nanchang 330096,China [3]Guangzhou Pharmaceutical Holdings Limited,Guangzhou 510130,China

出　　处：《Cancer Advances》2024年第12期1-6,共6页TMR肿瘤进展

基　　金：Authors of this research are in deep gratitude toward Professor Qin Wang from the Nanchang Research Institute,Sun Yat-sen University for her dedicated guidance and support to this work.This work was supported by the National Key R&D Program of China(2022YFC3500302);the Ministry of Science and Technology of China(No.2017YFC1703104);the Key Laboratory Project of Pharmaceutical Lipids in Guangdong Province(No.2020B1212070024);the Guangdong Province Key Areas R&D Program Project(No.2020B1111120002).

摘　　要：Purpose:This study aims to investigate whether Ganoderma lucidum spore oil(GLSO)could enhance the effect of paclitaxel(PTX),improve the tolerance to PTX and prolong the overall survival of Lewis tumor-bearing mice,which has never been reported before.Methods:The tumor,spleen,and thymus were weighed at the end of the experiment.Whole blood was collected for hematological index analysis,and the intact femur was removed to determine the bone marrow nucleated cell count(BMN).The percentage of lymphocytes in the spleen of mice was detected by flow cytometry,the activity of NK cells was detected by LDH assay,and the proliferation index of lymphocytes was determined by CCK-8 assay.The overall and mean survival time and life extension rate were calculated using SPSS software.Results:Our data showed that GLSO could enhance the anti-tumor effect of PTX and prolong the survival of mice.The underlying mechanisms of the above effects might be related to the toxic reduction effect of GLSO by relieving hematotoxicity,myelosuppression and immunosuppression.Specifically,GLSO could increase the number of blood cells and bone marrow cells,alleviate the thymic index,and elevate the number and activity of NK cells in mice treated with PTX.Conclusion:GLSO may enhance the efficacy of PTX by boosting the activity of immune NK cells and prolong survival by counteracting PTX-induced bone marrow alterations and improving hematopoiesis.These findings suggested the promising role of GLSO in combination with PTX to extend the survival and increase the tolerance of patients in clinical chemotherapy of lung cancer.

关 键 词：Ganoderma lucidum spore oil Traditional Chinese Medicine lung cancer PACLITAXEL TOLERANCE SURVIVAL 

分 类 号：R73[医药卫生—肿瘤]