Proteomics for early prenatal screening of gestational diabetes mellitus  

作　　者：Liang Wu Xiu-Ping Wang Yun-Xia Zhu Yan-Ping Tan Chun-Ming Li 

机构地区：[1]Department of Dermatology,The Second Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330006,Jiangxi Province,China [2]Department of Dermatology,Jiangxi Provincial Maternal and Child Health Hospital,Nanchang 330000,Jiangxi Province,China

出　　处：《World Journal of Clinical Cases》2024年第26期5850-5853,共4页世界临床病例杂志

摘　　要：In this editorial,we comment on the article by Cao et al.Through applying isobaric tags for relative and absolute quantification technology coupled with liquid chromatography-tandem mass spectrometry,the researchers observed significant differential expression of 47 proteins when comparing serum samples from pregnant women with gestational diabetes mellitus(GDM)to the healthy ones.GDM symptoms may involve abnormalities in inflammatory response,complement system,coagulation cascade activation,and lipid metabolism.Retinol binding protein 4 and angiopoietin like 8 are potential early indicators of GDM.GDM stands out as one of the most prevalent metabolic complications during pregnancy and is linked to severe maternal and fetal outcomes like pre-eclampsia and stillbirth.Nevertheless,none of the biomarkers discovered so far have demonstrated effectiveness in predicting GDM.Our topic was designed to foster insights into advances in the application of proteomics for early prenatal screening of GDM.

关 键 词：Gestational diabetes mellitus PROTEOMICS BIOMARKER BLOOD PLACENTA 

分 类 号：R714.256[医药卫生—妇产科学]