Overview of dyslipidemia and metabolic syndrome in myeloproliferative neoplasms  

作　　者：Mihnea-Alexandru Găman Bahadar Singh Srichawla Yong-Feng Chen Poulami Roy Arkadeep Dhali Ahmed Nahian Muhammad Romail Manan Vincent Kipkorir Richard Christian Suteja Lakshmi Venkata Simhachalam Kutikuppala Amelia Maria Găman Camelia Cristina Diaconu 

机构地区：[1]Faculty of Medicine,“Carol Davila”University of Medicine and Pharmacy,Bucharest 050474,Romania [2]Department of Hematology,Center of Hematolog [3]Department of Cellular and Molecular Pathology,Stefan S Nicolau Institute of Virology,Romanian Academy,Bucharest 030304,Romania [4]Department of Neurology,University of Massachusetts Chan Medical School,Worcester,MA 01655,United States [5]Department of Basic Medical Sciences,School of Medicine of Taizhou University,Taizhou University,Taizhou 318000,Zhejiang Province,China [6]Department of Medicine,North Bengal Medical College and Hospital,West Bengal 734012,India [7]Academic Department of Gastroenterology,Sheffield Teaching Hospitals NHS Foundation Trust,Sheffield S57AU,United Kingdom [8]Lecom at Seton Hill,Greensburg,PA 15601,United States [9]Faculty of Medicine,Services Hospital,Lahore 54000,Pakistan [10]Department of Human Anatomy and Physiology,University of Nairobi,Nairobi 00100,Kenya [11]Faculty of Medicine,Udayana University,Denpasar,Bali 80361,Indonesia [12]Department of General Surgery,Dr.NTR University of Health Sciences,Vijayawada 520008,Andhra Pradesh,India [13]Department of Pathophysiology,University of Medicine and Pharmacy of Craiova,Craiova 200349,Romania [14]Clinic of Hematology,Filantropia City Hospital,Craiova 200143,Romania [15]Department of Internal Medicine,Faculty of Medicine,“Carol Davila”University of Medicine and Pharmacy,Bucharest 050474,Romania [16]Internal Medicine Clinic,Clinical Emergency Hospital of Bucharest,Bucharest 105402,Romania

出　　处：《World Journal of Clinical Oncology》2024年第6期717-729,共13页世界临床肿瘤学杂志（英文版）

基　　金：Supported by the Grant Funded by Competitiveness Operational Programme A1.1.4.ID:P_37_798 MYELOAL-EDIAPROT(to Găman MA),No.149/26.10.2016(MySMIS2014+:106774).

摘　　要：Myeloproliferative neoplasms(MPNs)occur due to the abnormal proliferation of one or more terminal myeloid cell lines in peripheral blood.Subjects suffering from MPNs display a high burden of cardiovascular risk factors,and thrombotic events are often the cause of death in this population of patients.Herein,we provide a brief overview of dyslipidemia and metabolic syndrome and their epidemiology in MPNs and examine the common molecular mechanisms between dyslipidemia,metabolic syndrome,and MPNs,with a special focus on cardio-vascular risk,atherosclerosis,and thrombotic events.Furthermore,we investigate the impact of dyslipidemia and metabolic syndrome on the occurrence and survival of thrombosis in MPN patients,as well as the management of dyslipidemia in MPNs,and the impact of MPN treatment on serum lipid concentrations,particularly as side/adverse effects reported in the context of clinical trials.

关 键 词：Polycythemia vera Essential thrombocythemia MYELOFIBROSIS Cardiovascular disease HYPERCHOLESTEROLEMIA HYPERTRIGLYCERIDEMIA OBESITY Diabetes Inflammation Oxidative stress 

分 类 号：R733.3[医药卫生—肿瘤]