Pro and anti-inflammatory diets as strong epigenetic factors in inflammatory bowel disease  

作　　者：Adele Rostami Kristen White Kamran Rostami 

机构地区：[1]Digestive Health Clinic,Palmerston North 4410,New Zealand [2]Digestive Health Clinic&Kōtare Wellness Ltd,Palmerston North 4410,New Zealand [3]Department of Gastroenterology,Palmerston North Hospital,Palmerston North 4442,New Zealand

出　　处：《World Journal of Gastroenterology》2024年第27期3284-3289,共6页世界胃肠病学杂志（英文版）

摘　　要：Inflammatory bowel disease(IBD)is the consequence of a complex interplay between environmental factors,like dietary habits,that alter intestinal microbiota in response to luminal antigens in genetically susceptible individuals.Epigenetics represents an auspicious area for the discovery of how environmental factors influence the pathogenesis of inflammation,prognosis,and response to therapy.Consequently,it relates to gene expression control in response to environmental influences.The increasing number of patients with IBD globally is indicative of the negative effects of a food supply rich in trans and saturated fats,refined su-gars,starches and additives,as well as other environmental factors like seden-tarism and excess bodyweight,influencing the promotion of gene expression and increasing DNA hypomethylation in IBD.As many genetic variants are now associated with Crohn's disease(CD),new therapeutic strategies targeting modi-fiable environmental triggers,such as the implementation of an anti-inflammatory diet that involves the removal of potential food antigens,are of growing interest in the current literature.Diet,as a strong epigenetic factor in the pathogenesis of inflammatory disorders like IBD,provides novel insights into the pathophysio-logy of intestinal and extraintestinal inflammatory disorders.

关 键 词：Inflammatory bowel disease EPIGENETIC Anti-inflammatory diet IMMUNOGENETICS MICROBIOME Polymeric diet Elemental diet 

分 类 号：R574[医药卫生—消化系统]