Interleukins in Epilepsy:Friend or Foe  

作　　者：Yuan Dong Xia Zhang Ying Wang 

机构地区：[1]Neuropsychiatry Research Institute,The Affiliated Hospital of Qingdao University,Qingdao University,Qingdao,266000,China [2]Program in Cellular and Molecular Medicine,Boston Children’s Hospital,Boston,MA,02115,USA

出　　处：《Neuroscience Bulletin》2024年第5期635-657,共23页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(82003729);the Natural Science Foundation of Shandong Province(ZR2022QH144 and ZR2020QH357).

摘　　要：Epilepsy is a chronic neurological disorder with recurrent unprovoked seizures,affecting~65 million worldwide.Evidence in patients with epilepsy and animal models suggests a contribution of neuroinflammation to epileptogenesis and the development of epilepsy.Interleukins(ILs),as one of the major contributors to neuroinflammation,are intensively studied for their association and modulatory effects on ictogenesis and epileptogenesis.ILs are commonly divided into pro-and anti-inflammatory cytokines and therefore are expected to be pathogenic or neuroprotective in epilepsy.However,both protective and destructive effects have been reported for many ILs.This may be due to the complex nature of ILs,and also possibly due to the different disease courses that those ILs are involved in.In this review,we summarize the contributions of different ILs in those processes and provide a current overview of recent research advances,as well as preclinical and clinical studies targeting ILs in the treatment of epilepsy.

关 键 词：EPILEPSY INTERLEUKINS NEUROINFLAMMATION 

分 类 号：R-332[医药卫生] R742.1