Phase separation and transcriptional regulation in cancer development  

作　　者：Yan Gu Ke Wei Jun Wang 

机构地区：[1]Department of Thoracic Surgery,Jiangsu Province Hospital,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China

出　　处：《Journal of Biomedical Research》2024年第4期307-321,共15页生物医学研究杂志（英文版）

基　　金：supported by the Jiangsu Province Natural Science Foundation(Grant No.BK20201492);the Key Medical Research Project of Jiangsu Provincial Health Commission(Grant No.K2019002);the Clinical Capacity Improvement Project of Jiangsu Province People's Hospital(Grant No.JSPH-MA-2021-8).

摘　　要：Liquid-liquid phase separation,a novel biochemical phenomenon,has been increasingly studied for its medical applications.It underlies the formation of membrane-less organelles and is involved in many cellular and biological processes.During transcriptional regulation,dynamic condensates are formed through interactions between transcriptional elements,such as transcription factors,coactivators,and mediators.Cancer is a disease characterized by uncontrolled cell proliferation,but the precise mechanisms underlying tumorigenesis often remain to be elucidated.Emerging evidence has linked abnormal transcriptional condensates to several diseases,especially cancer,implying that phase separation plays an important role in tumorigenesis.Condensates formed by phase separation may have an effect on gene transcription in tumors.In the present review,we focus on the correlation between phase separation and transcriptional regulation,as well as how this phenomenon contributes to cancer development.

关 键 词：phase separation transcription regulation CANCER super-enhancer CONDENSATES 

分 类 号：R73[医药卫生—肿瘤]