CONDENSATES

作品数:91被引量:60H指数:3
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Stress granules:Guardians of cellular health and triggers of disease
《Neural Regeneration Research》2026年第2期588-597,共10页Meghal Desai Keya Gulati Manasi Agrawal Shruti Ghumra Pabitra KSahoo 
supported by a grant from the Merkin Peripheral Neuropathy and Nerve Regeneration Center(to PKS);the Rutgers University Startup Fund(to PKS).
Stress granules are membraneless organelles that serve as a protective cellular response to external stressors by sequestering non-translating messenger RNAs(mRNAs)and regulating protein synthesis.Stress granules form...
关键词:apoptosis axon regeneration biomolecular condensates germline cell development mRNA transport NEURODEGENERATION NEURODEVELOPMENT PATHOPHYSIOLOGY physiological functions stress granules translation viral infection 
Superradiant growth anomaly magnification in evolution of vector bosonic condensates bounded by a Kerr black hole with near-horizon reflection
《Science China(Physics,Mechanics & Astronomy)》2025年第4期62-81,共20页Nayun Jia Yin-Da Guo Gui-Rong Liang Zhan-Feng Mai Xin Zhang 
supported by the National Natural Science Foundation of China(Grant Nos.12147163,and 12175099);supported by the National Natural Science Foundation of China(Grant No.12075136);supported by the National Natural Science Foundation of China(Grant No.12247128);supported by the National Natural Science Foundation of China(Grant Nos.11975072,11835009,and 12473001);supported by Jiangsu Funding Program for Excellent Postdoctoral Talent;the Natural Science Foundation of Shandong Province(Grant No.ZR2020MA094);the National SKA Program of China(Grant Nos.2022SKA0110200,and 2022SKA0110203);the 111 Project(Grant No.B16009)。
Ultralight vector particles can form evolving condensates around a Kerr black hole(BH)due to superradiant instability.We study the effect of near-horizon reflection on the evolution of this system:by matching three pi...
关键词:SUPERRADIANCE ultralight boson black hole gravitational wave near-horizon reflection 
Enhanced cofactor recycling and accelerated reaction rate via liquid-liquid phase separation in dual-enzyme condensates
《Chinese Journal of Catalysis》2025年第2期135-148,共14页Jiaxu Liu Jiaxin Chen Xiaoyan Zhang Daidi Fan Yunpeng Bai 
国家重点研发计划(2023YFA0913600);国家自然科学基金(22378120,22078096)。
Enzyme catalysis is a promising way to produce chiral products in a green and sustainable way.However,the high cost of cofactors and their relatively low recycling efficiency hinder the widespread application of enzym...
关键词:Cofactor recycling CONDENSATE Proximity effect Intrinsically disordered region Enzyme catalysis 
ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling
《Protein & Cell》2025年第1期64-71,共8页Jingdong Xue Siang Lv Ming Yu Yixuan Pan Ningzhe Li Xiang Xu Qi Zhang Mengyuan Peng Fang Liu Xuxu Sun Yimin Lao Yanhua Yao Juan Song Jun Wu Bing Li 
supported by the National Key R&D Program of China(2021YFA1300100 to B.L.);the National Natural Science Foundation of China(32030019,31872817 to B.L.,82072892 to J.W.,81901284 to YH.Y.,32000413 to J.S.,31970587,32170609 to X.S.);the Natural Science Foundation of Guangxi(No.2023GXNSFAA026276 to J.W.);the Fundamental Research Funds for the Central Universities.
Dear Editor,The human SWI/SNF chromatin remodeling complexes are essential for modulating genomic architecture and increasing DNA accessibility,thereby regulating gene transcription(Clapier et al.,2017).These complexe...
关键词:REMODELING ARID1A 
Biomolecular condensates modulate membrane remodeling
《Molecular Plant》2025年第1期17-18,共2页Emma K.Meese Lucia C.Strader 
supported by the National Science Foundation(PGRP BIO-2112056);the National Institutes of Health(R35 GM136338);Duke Beyond the Horizons funds.
Cellular function relies on numerous diverse processes,all happening simultaneously.One means by which cells manage these processes is through the use of biomolecular condensates.These membrane-less compartments,often...
关键词:FORCES KINETICS BENDING 
Navigating biomolecular condensates in plants from patterns to functions
《Molecular Plant》2024年第9期1329-1332,共4页Yansong Miao Monika Chodasiewicz Xiaofeng Fang 
support from the Ministry of Science and Technology of China(2022YFA1303400);NSFC(32222015)to X.F.;KAUST for the financial support to M.C.,and Singapore MOE-T2EP30121-0015,MOE-T2EP30122-0021,MOE2019-T3-1-012,and NRF-NRFI08-2022-0012 to Y.M.
Biomolecular condensates have emerged as one of the important focuses of recent research on plant biology.The study of these condensates often begins with evidence gathered from imaging or bioinformatics analyses.Comb...
关键词:functions. CONDENSATION DIRECTIONS 
Biomolecular condensates and disease pathogenesis
《Science China(Life Sciences)》2024年第9期1792-1832,共41页Ke Ruan Ge Bai Yanshan Fang Dan Li Tingting Li Xingguo Liu Boxun Lu Qing Lu Zhou Songyang Shuguo Sun Zheng Wang Xin Zhang Wen Zhou Hong Zhang 
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0480000);the National Key Research and Development Program of China(2022YFA1103800,2022YFA1303100,2023YFE0210100);the National Natural Science Foundation of China(22337005,22377119,32025010,32241002,32270812,32270920,32325016,32350024,32261160376,82150003,82188101,82325016,92157202,92254301,T2325003);STI2030-Major Projects(2021ZD0202501);the Science and Technology Commission of Shanghai Municipality(2019SHZDZX02,20490712600);the Key Research Program CAS(ZDBS-ZRKJZ-TLC003);International Cooperation Program CAS(154144KYSB20200006);CAS Project for Young Scientists in Basic Research(YSBR-075);Guangdong Province Science and Technology Program(2023B1111050005,2023B1212060050);Natural Science Foundation of Anhui Province(2108085J12);Center for Advanced Interdisciplinary Science and Biomedicine of IHM(QYPY20220008);Shenzhen Talent Program(KQTD20210811090115021);Guangdong Innovative and Entrepreneurial Research Team Program(2021ZT09Y104)。
Biomolecular condensates or membraneless organelles(MLOs)formed by liquid-liquid phase separation(LLPS)divide intracellular spaces into discrete compartments for specific functions.Dysregulation of LLPS or aberrant ph...
关键词:liquid-liquid phase separation biomolecular condensate membraneless organelle 
Phase separation and transcriptional regulation in cancer development被引量:1
《Journal of Biomedical Research》2024年第4期307-321,共15页Yan Gu Ke Wei Jun Wang 
supported by the Jiangsu Province Natural Science Foundation(Grant No.BK20201492);the Key Medical Research Project of Jiangsu Provincial Health Commission(Grant No.K2019002);the Clinical Capacity Improvement Project of Jiangsu Province People's Hospital(Grant No.JSPH-MA-2021-8).
Liquid-liquid phase separation,a novel biochemical phenomenon,has been increasingly studied for its medical applications.It underlies the formation of membrane-less organelles and is involved in many cellular and biol...
关键词:phase separation transcription regulation CANCER super-enhancer CONDENSATES 
PABP-driven secondary condensed phase within RSV inclusion bodies activates viral mRNAs for ribosomal recruitment
《Virologica Sinica》2024年第2期235-250,共16页Qiang Zhang Hanzhe Ye Cong Liu Haiwu Zhou Mingbin He Xiaodong Liang Yu Zhou Kun Wang Yali Qin Zhifei Li Mingzhou Chen 
supported by the grants from National Key R&D Program of China(2021YFC2300702 and 2021YFC2300200);the Hubei Provincial Natural Science Foundation of China(2021CFB364);the National Natural Science Foundation of China(82130064,81825015,U22A20337 and 32000119);the Key Biosafety Science and Technology Program of Hubei Jiangxia Laboratory(JXBS001).
Inclusion bodies(IBs)of respiratory syncytial virus(RSV)are formed by liquid-liquid phase separation(LLPS)and contain internal structures termed“IB-associated granules”(IBAGs),where anti-termination factor M2-1 and ...
关键词:Respiratory syncytial virus(RSV) Inclusion bodies(IBs) Biomolecular condensates Liquid-liquid phase separation(LLPS) Secondary condensed phase mRNA activation 
Plant RNA-binding proteins:Phase separation dynamics and functional mechanisms underlying plant development and stress responses被引量:1
《Molecular Plant》2024年第4期531-551,共21页Sheng Fan Yu Zhang Shaobo Zhu Lisha Shen 
supported by the National Research Foundation Competitive Research Programme(NRF-CRP22-2019-0001);the intramural funding from Temasek Life Sciences Laboratory。
RNA-binding proteins(RBPs)accompany RNA from synthesis to decay,mediating every aspect of RNA metabolism and impacting diverse cellular and developmental processes in eukaryotes.Many RBPs undergo phase separation alon...
关键词:RNA-binding proteins phase separation biomolecular condensates RNA metabolism development stress resilience 
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