supported by a grant from the Merkin Peripheral Neuropathy and Nerve Regeneration Center(to PKS);the Rutgers University Startup Fund(to PKS).
Stress granules are membraneless organelles that serve as a protective cellular response to external stressors by sequestering non-translating messenger RNAs(mRNAs)and regulating protein synthesis.Stress granules form...
supported by the National Natural Science Foundation of China(Grant Nos.12147163,and 12175099);supported by the National Natural Science Foundation of China(Grant No.12075136);supported by the National Natural Science Foundation of China(Grant No.12247128);supported by the National Natural Science Foundation of China(Grant Nos.11975072,11835009,and 12473001);supported by Jiangsu Funding Program for Excellent Postdoctoral Talent;the Natural Science Foundation of Shandong Province(Grant No.ZR2020MA094);the National SKA Program of China(Grant Nos.2022SKA0110200,and 2022SKA0110203);the 111 Project(Grant No.B16009)。
Ultralight vector particles can form evolving condensates around a Kerr black hole(BH)due to superradiant instability.We study the effect of near-horizon reflection on the evolution of this system:by matching three pi...
Enzyme catalysis is a promising way to produce chiral products in a green and sustainable way.However,the high cost of cofactors and their relatively low recycling efficiency hinder the widespread application of enzym...
supported by the National Key R&D Program of China(2021YFA1300100 to B.L.);the National Natural Science Foundation of China(32030019,31872817 to B.L.,82072892 to J.W.,81901284 to YH.Y.,32000413 to J.S.,31970587,32170609 to X.S.);the Natural Science Foundation of Guangxi(No.2023GXNSFAA026276 to J.W.);the Fundamental Research Funds for the Central Universities.
Dear Editor,The human SWI/SNF chromatin remodeling complexes are essential for modulating genomic architecture and increasing DNA accessibility,thereby regulating gene transcription(Clapier et al.,2017).These complexe...
supported by the National Science Foundation(PGRP BIO-2112056);the National Institutes of Health(R35 GM136338);Duke Beyond the Horizons funds.
Cellular function relies on numerous diverse processes,all happening simultaneously.One means by which cells manage these processes is through the use of biomolecular condensates.These membrane-less compartments,often...
support from the Ministry of Science and Technology of China(2022YFA1303400);NSFC(32222015)to X.F.;KAUST for the financial support to M.C.,and Singapore MOE-T2EP30121-0015,MOE-T2EP30122-0021,MOE2019-T3-1-012,and NRF-NRFI08-2022-0012 to Y.M.
Biomolecular condensates have emerged as one of the important focuses of recent research on plant biology.The study of these condensates often begins with evidence gathered from imaging or bioinformatics analyses.Comb...
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0480000);the National Key Research and Development Program of China(2022YFA1103800,2022YFA1303100,2023YFE0210100);the National Natural Science Foundation of China(22337005,22377119,32025010,32241002,32270812,32270920,32325016,32350024,32261160376,82150003,82188101,82325016,92157202,92254301,T2325003);STI2030-Major Projects(2021ZD0202501);the Science and Technology Commission of Shanghai Municipality(2019SHZDZX02,20490712600);the Key Research Program CAS(ZDBS-ZRKJZ-TLC003);International Cooperation Program CAS(154144KYSB20200006);CAS Project for Young Scientists in Basic Research(YSBR-075);Guangdong Province Science and Technology Program(2023B1111050005,2023B1212060050);Natural Science Foundation of Anhui Province(2108085J12);Center for Advanced Interdisciplinary Science and Biomedicine of IHM(QYPY20220008);Shenzhen Talent Program(KQTD20210811090115021);Guangdong Innovative and Entrepreneurial Research Team Program(2021ZT09Y104)。
Biomolecular condensates or membraneless organelles(MLOs)formed by liquid-liquid phase separation(LLPS)divide intracellular spaces into discrete compartments for specific functions.Dysregulation of LLPS or aberrant ph...
supported by the Jiangsu Province Natural Science Foundation(Grant No.BK20201492);the Key Medical Research Project of Jiangsu Provincial Health Commission(Grant No.K2019002);the Clinical Capacity Improvement Project of Jiangsu Province People's Hospital(Grant No.JSPH-MA-2021-8).
Liquid-liquid phase separation,a novel biochemical phenomenon,has been increasingly studied for its medical applications.It underlies the formation of membrane-less organelles and is involved in many cellular and biol...
supported by the grants from National Key R&D Program of China(2021YFC2300702 and 2021YFC2300200);the Hubei Provincial Natural Science Foundation of China(2021CFB364);the National Natural Science Foundation of China(82130064,81825015,U22A20337 and 32000119);the Key Biosafety Science and Technology Program of Hubei Jiangxia Laboratory(JXBS001).
Inclusion bodies(IBs)of respiratory syncytial virus(RSV)are formed by liquid-liquid phase separation(LLPS)and contain internal structures termed“IB-associated granules”(IBAGs),where anti-termination factor M2-1 and ...
supported by the National Research Foundation Competitive Research Programme(NRF-CRP22-2019-0001);the intramural funding from Temasek Life Sciences Laboratory。
RNA-binding proteins(RBPs)accompany RNA from synthesis to decay,mediating every aspect of RNA metabolism and impacting diverse cellular and developmental processes in eukaryotes.Many RBPs undergo phase separation alon...