茶多酚抗肥胖的研究进展  

Research Progress on Anti Obesity Effects of Tea Polyphenols

作　　者：王菲 燕树勋[2] 王萍[2] WANG Fei;YAN Shuxun;WANG Ping(The First Clinical Medical College of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Department Endocrinology WardⅡ,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450008,China)

机构地区：[1]河南中医药大学第一临床医学院,河南郑州450000 [2]河南中医药大学第一附属医院内分泌科二病区,河南郑州450008

出　　处：《食品工业科技》2024年第16期474-479,共6页Science and Technology of Food Industry

基　　金：河南省科技攻关项目(232102310431);河南省中医药传承与创新人才工程(仲景工程)中医药拔尖人才(CZ0237-02);郑州市科技惠民计划(2021KJHM0017)。

摘　　要：肥胖是糖尿病、心血管疾病、肿瘤等若干慢性疾病的主要风险因素和病理基础,目前已成为全球公共卫生健康问题之一。随着肥胖率的增高,对于天然抗肥胖药物的研究和应用已经成为人们持续关注的热点。茶多酚(Tea Polyphenols,TP)是茶叶中多酚类物质的总称,在茶叶中含量丰富、功效显著,大量研究表明其在抗肥胖方面具有良好的效果,发展前景广。本文围绕茶多酚抗肥胖,综述了近年来在体外,动物和临床研究中的研究进展,并分别从茶多酚调节肠道菌群的结构和组成,调节炎症反应,促进能量消耗,调控相关酶的活性并抑制脂类的合成和吸收等途径探讨防治肥胖的机制,以期为开发含天然茶多酚的减肥食品或药物奠定基础。Obesity is a major risk factor and pathological basis for several chronic diseases such as diabetes,cardiovascular diseases,and tumors.It has now become a global public health issue.With the increasing prevalence of obesity,research and application of natural anti-obesity drugs have become a continuous focus of attention.Tea polyphenols(TP),collectively known as polyphenolic substances in tea,are abundant and significant in their effects in tea.Numerous studies have shown that tea polyphenols have good anti-obesity effects and promising prospects.This article reviews the research progress on tea polyphenols and their anti-obesity effects in recent years,focusing on in vitro,animal,and clinical studies.It discusses the mechanisms of preventing and treating obesity through tea polyphenols,including the regulation of intestinal microbiota composition,modulation of inflammatory response,promotion of energy expenditure,regulation of enzyme activity,and inhibition of lipid synthesis and absorption.The aim is to lay a foundation for the development of natural tea polyphenol-based weight-loss foods or drugs.

关 键 词：肥胖 茶多酚 肠道菌群 炎症反应 能量代谢 

分 类 号：TS201.4[轻工技术与工程—食品科学]