Navigating the labyrinth of long non-coding RNAs in colorectal cancer:From chemoresistance to autophagy  

作　　者：Jia-Mei Yu Chong-Qi Sun Huan-Huan Xu Ya-Li Jiang Xing-Yu Jiang Si-Qi Ni Ting-Yu Zhao Ling-Xiang Liu 

机构地区：[1]Department of Oncology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China [2]Department of Hematology and Oncology,Department of Geriatric Lung Cancer Research Laboratory,Jiangsu Province Geriatric Hospital,Nanjing 210009,Jiangsu Province,China [3]Central Laboratory,The Friendship Hospital of Ili Kazakh Autonomous Prefecture,Ili&Jiangsu Joint Institute of Health,Yining 835000,Xinjiang Uyghur Autonomous Region,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第8期3376-3381,共6页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：Supported by the National Natural Science Foundation of China,No.81472782;National Clinical Key Specialty Department(Oncology)of China,No.YWC-ZKJS-2023-01;Research Fund of Yili Institute of Clinical Medicine,No.yl2021ms02.

摘　　要：Long non-coding RNAs(lncRNAs),with transcript lengths exceeding 200 nucleotides and little or no protein-coding capacity,have been found to impact colorectal cancer(CRC)through various biological processes.LncRNA expression can regulate autophagy,which plays dual roles in the initiation and progression of cancers,including CRC.Abnormal expression of lncRNAs is associated with the emergence of chemoresistance.Moreover,it has been confirmed that targeting autophagy through lncRNA regulation could be a viable approach for combating chemoresistance.Two recent studies titled“Human β-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long non-coding RNA TCONS_00014506”and“Upregulated lncRNA PRNT promotes progression and oxaliplatin resistance of colorectal cancer cells by regulating HIPK2 transcription”revealed novel insights into lncRNAs associated with autophagy and oxaliplatin resistance in CRC,respectively.In this editorial,we particularly focus on the regulatory role of lncRNAs in CRC-related autophagy and chemoresistance since the regulation of chemotherapeutic sensitivity by intervening with the lncRNAs involved in the autophagy process has become a promising new approach for cancer treatment.

关 键 词：Long non-coding RNA AUTOPHAGY CHEMORESISTANCE OXALIPLATIN Colorectal cancer 

分 类 号：R735.34[医药卫生—肿瘤]