Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum  

作　　者：Li-Li Yin Ping-Qian Qi Yun-Fei Hu Xiao-Jun Fu Rui-Shan He Meng-Meng Wang Yan-Juan Deng Su-Yi Xiong Qi-Wen Yu Jin-Ping Hu Lv Zhou Zhi-Bin Zhou Ying Xiong Huan Deng 

机构地区：[1]The Affiliated Rehabilitation Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330006,Jiangxi Province,China [2]The Fourth Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330006,Jiangxi Province,China [3]The Second College of Clinical Medicine,Jiangxi Medical College,Nanchang University,Nanchang 330006,Jiangxi Province,China [4]Tumor Immunology Institute,Nanchang University,Nanchang 330006,Jiangxi Province,China [5]Department of General Medicine,The Second College of Clinical Medicine,Jiangxi Medical College,Nanchang University,Nanchang 330031,Jiangxi Province,China [6]The Ministry of Education Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors,Jiangxi Medical College,Nanchang University,Nanchang 330031,Jiangxi Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第8期3600-3623,共24页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：Supported by National Science Foundation of China,No.82160546;the Science Foundation of Jiangxi Province,No.20202BBG73027;the Foundation of Jiangxi Province for Distinguished Scholars,No.jxsq2023201020;the Science and Technology Project of Jiangxi Administration of Traditional Chinese Medicine,No.2022B789.

摘　　要：BACKGROUND Colorectal polyps,which are characterized by a high recurrence rate,represent preneoplastic conditions of the intestine.Due to unclear mechanisms of pathogenesis,first-line therapies for non-hereditary recurrent colorectal polyps are limited to endoscopic resection.Although recent studies suggest a mechanistic link between intestinal dysbiosis and polyps,the exact compositions and roles of bacteria in the mucosa around the lesions,rather than feces,remain unsettled.AIM To clarify the composition and diversity of bacteria in the mucosa surrounding or 10 cm distal to recurrent intestinal polyps.METHODS Mucosal samples were collected from four patients consistently with adenomatous polyps(Ade),seven consistently with non-Ade(Pol),ten with current Pol but previous Ade,and six healthy individuals,and bacterial patterns were evaluated by 16S rDNA sequencing.Linear discriminant analysis and Student’s t-tests were used to identify the genus-level bacteria differences between groups with different colorectal polyp phenotypes.Pearson’s correlation coefficients were used to evaluate the correlation between intestinal bacteria at the genus level and clinical indicators.RESULTS The results confirmed a decreased level of probiotics and an enrichment of pathogenic bacteria in patients with all types of polyps compared to healthy individuals.These changes were not restricted to the mucosa within 0.5 cm adjacent to the polyps,but also existed in histologically normal tissue 10 cm distal from the lesions.Significant differences in bacterial diversity were observed in the mucosa from individuals with normal conditions,Pol,and Ade.Increased abundance of Gram-negative bacteria,including Klebsiella,Plesiomonas,and Cronobacter,was observed in Pol group and Ade group,suggesting that resistance to antibiotics may be one risk factor for bacterium-related harmful environment.Meanwhile,age and gender were linked to bacteria changes,indicating the potential involvement of sex hormones.CONCLUSION These preliminary results suppo

关 键 词：DYSBIOSIS BIOPSY POLYP Bacteria COLORECTUM 

分 类 号：R735.34[医药卫生—肿瘤]