Current perspectives on mesenchymal stem cells as a potential therapeutic strategy for non-alcoholic fatty liver disease  

作　　者：Yan Jiang Narazah Mohd Yusoff Jiang Du Emmanuel Jairaj Moses Jun-Tang Lin 

机构地区：[1]School of Nursing,Xinxiang Medical University,Xinxiang 453000,Henan Province,China [2]Department of Biomedical Sciences,Advanced Medical and Dental Institute,Universiti Sains Malaysia,Kepala Batas 13200,Pulau Pinang,Malaysia [3]Advanced Medical and Dental Institute,Universiti Sains Malaysia,Kepala Batas 13200,Pulau Pinang,Malaysia [4]Henan Joint International Research Laboratory of Stem Cell Medicine,School of Medical Engineering,Xinxiang Medical University,Xinxiang 453003,Henan Province,China [5]Stem Cells and Biotherapy Engineering Research Center of Henan,National Joint Engineering Laboratory of Stem Cells and Biotherapy,School of Life Science and Technology,Xinxiang Medical University,Xinxiang 453003,Henan Province,China [6]Henan Joint International Research Laboratory of Stem Cell Medicine,School of Medical Engineering,Xinxiang Medical University,Xinxiang 453000,Henan Province,China

出　　处：《World Journal of Stem Cells》2024年第7期760-772,共13页世界干细胞杂志（英文版）（电子版）

摘　　要：Non-alcoholic fatty liver disease(NAFLD)has emerged as a significant health challenge,characterized by its widespread prevalence,intricate natural progression and multifaceted pathogenesis.Although NAFLD initially presents as benign fat accumulation,it may progress to steatosis,non-alcoholic steatohepatitis,cirrhosis,and hepatocellular carcinoma.Mesenchymal stem cells(MSCs)are recognized for their intrinsic self-renewal,superior biocompatibility,and minimal immunogenicity,positioning them as a therapeutic innovation for liver diseases.Therefore,this review aims to elucidate the potential roles of MSCs in alleviating the progression of NAFLD by alteration of underlying molecular pathways,including glycolipid metabolism,inflammation,oxidative stress,endoplasmic reticulum stress,and fibrosis.The insights are expected to provide further understanding of the potential of MSCs in NAFLD therapeutics,and support the development of MSC-based therapy in the treatment of NAFLD.

关 键 词：Non-alcoholic induced fatty liver disease Mesenchymal stem cells Lipid accumulation INFLAMMATION Oxidative stress Endoplasmic reticulum stress FIBROSIS 

分 类 号：R575[医药卫生—消化系统]