制药化工仿真工厂构建及其在高职实践教学中的应用  

Construction of Pharmaceutical and Chemical Simulation Factory and Its Application in Vocational Practice Teaching

作　　者：陶雪芬[1] 龚顺泽 金银秀[1] 王玉新[1] 柯中炉[1] 郭晶晶 TAO Xue-Fen;GONG Shun-Ze;JIN Yin-Xiu;WANG Yu-Xin;KE Zhong-Lu;GUO Jing-Jin(College of Medicine&.Pharmaceutical Engineering,Taizhou Vocational&Technical College,Taizhou 318000,China)

机构地区：[1]台州职业技术学院医学与制药工程学院,浙江台州318000

出　　处：《化学教育（中英文）》2024年第16期66-73,共8页Chinese Journal of Chemical Education

基　　金：浙江省高职教育“十四五”第一批教学改革项目(jg20230241);教育部高等学校科学研究发展中心2022年度“虚拟仿真技术在职业教育教学中的创新应用”专项课题(ZJXF2022001)。

摘　　要：实践训练是高职制药化工技能人才培养的重要环节,为解决传统化工实践教学与企业真实生产情况脱节问题,详细介绍了以诺氟沙星原料药生产为模型载体,依托信息技术和3D工厂仿真技术,构建包含硝化、氟化、环合等8个工序,以空气、水和中性固体颗粒代替真实物料的半实物仿真工厂的过程。应用该仿真工厂开展理虚实一体教学实践,取得了良好的育人效果。Practical training is an important part of cultivating the talented persons in pharmaceutical and chemical engineering in higher vocational colleges.In order to overcome the disconnection between traditional chemical engineering practice teaching and the actual production status of enterprises,we introduced the detailed process of building a semi physical simulation factory including eight process such as nitrification,fluorination,and cyclization,using norfloxacin raw material production as a model carrier,relying on information technology and 3D factory simulation technology.Air,water and neutral solid particles were used to replace real materials.The application of this simulation factory in the integrated teaching practice of theory,virtuality,and reality had achieved good educational results.

关 键 词：半实物仿真 诺氟沙星 化学制药 合成工艺 实践教学 

分 类 号：G712.4[文化科学—职业技术教育学] TQ460.8-4[文化科学—教育学]