基于GC-QTOF-MS对物理回收的食品接触用再生高密度聚乙烯中迁移物的非靶向筛查  

Non-targeted Screening for Migrants in Physically Recycled Food Contact High-Density Polyethylene Using Gas Chromatography Quadrupole Time-of-Flight-Mass Spectrometry

作　　者：张浩然[1] 曾少甫 刘宜奇 王志伟[1,2] 胡长鹰 ZHANG Haoran;ZENG Shaofu;LIU Yiqi;WANG Zhiwei;HU Changying(College of Packaging Engineering,Jinan University,Zhuhai 519070,China;School of Mechanics and Construction Engineering,Jinan University,Guangzhou 510632,China;Department of Food Science and Engineering,Jinan University,Guangzhou 510632,China)

机构地区：[1]暨南大学包装工程学院,广东珠海519070 [2]暨南大学力学与建筑工程学院,广东广州510632 [3]暨南大学食品科学与工程系,广东广州510632

出　　处：《食品科学》2024年第17期226-232,共7页Food Science

基　　金：国家自然科学基金国际(地区)合作研究项目(32061160474)。

摘　　要：以3家企业提供的21?种食品接触用再生高密度聚乙烯(recycled high-density polyethylene,rHDPE)样品在60℃条件下与两种代表性食品模拟物(95%乙醇、4%乙酸溶液)接触10 d作为迁移实验条件,利用气相色谱-串联四极杆飞行时间质谱检测迁移到食品模拟物中的物质。被筛查出的161种物质根据其毒性进行分级(由低至高分为Ⅰ~Ⅳ级),其中毒性Ⅲ和Ⅳ级的有59种,且其预测辛醇/水分配系数大于毒性Ⅰ、Ⅱ级的物质。被筛查的物质中苯及取代衍生物占比最高。邻苯类增塑剂、抗氧剂降解产物以及多环芳烃等物质需要特别关注。使用正交偏最小二乘判别分析迁移物在不同阶段样品中的迁移量变化,发现终产品相较母粒样品中物质的迁移量有所提升。该研究可以为食品接触用r HDPE中迁移物的分析及安全风险评估提供理论基础。A total of 21 kinds of recycled high-density polyethylene(rHDPE)in contact with food were selected from three companies.Migration experiments were performed by contacting these samples with two representative food simulants(95%ethanol and 4%acetic acid)at 60℃for 10 days.The migration of substances to food simulants was detected by gas chromatography quadrupole time-of-flight-mass spectrometry(GC-QTOF-MS).Altogether 161 substances were selected and classified into four grades in decreasing order of toxicity(Ⅰ–Ⅳ),among which 59 substances belonged to grades Ⅲ and Ⅳ,and their predicted octanol/water partition coefficient(XLogP)was greater than that of the substances belonging to grades Ⅰ and Ⅱ.Benzene and substituted derivatives accounted for the highest proportion of all selected substances.Special attention should be paid to phenylester plasticizers,degradation products of antioxidants and polycyclic aromatic hydrocarbon(PAHs).Changes in the migration of substances from the samples were analyzed using orthogonal partial least squares-discriminant analysis(OPLS-DA),and it was found that the migration of substances from the final products was elevated compared with that from the masterbatch samples.This study can provide a theoretical basis for the analysis and safety risk assessment of migrating substances in rHDPE in contact with food.

关 键 词：再生高密度聚乙烯 迁移 气相色谱-串联四极杆飞行时间质谱 正交偏最小二乘判别分析 

分 类 号：TS201.6[轻工技术与工程—食品科学]