Modeling human gastric cancers in immunocompetent mice  

作　　者：Weihong Zhang Shilong Wang Hui Zhang Yan Meng Shi Jiao Liwei An Zhaocai Zhou 

机构地区：[1]Department of Stomatology,Department of Medical Ultrasound,Shanghai Tenth People's Hospital,Tongji University Cancer Center,Tongji University School of Medicine,Shanghai 200072,China [2]State Key Laboratory of Genetic Engineering,School of Life Sciences,Zhongshan Hospital,Fudan University,Shanghai 200032,China [3]Collaborative Innovation Center for Cancer Personalized Medicine,School of Public Health,Nanjing Medical University,Nanjing 211166,China

出　　处：《Cancer Biology & Medicine》2024年第7期553-570,共18页癌症生物学与医学（英文版）

基　　金：supported by the National Key R&D Program of China(Grant No.2020YFA0803200 and 2023YFC2505903);National Natural Science Foundation of China(Grant Nos.82003014,31930026,81972876,82150112,92168116,81725014,81822035,and 82222052);China Postdoctoral Science Foundation(Grant No.2020M671231);Fundamental Research Funds for the Central Universities(Grant No.22120240327)。

摘　　要：Gastric cancer(GC)is a major cause of cancer-related mortality worldwide.GC is determined by multiple(epi)genetic and environmental factors;can occur at distinct anatomic positions of the stomach;and displays high heterogeneity,with different cellular origins and diverse histological and molecular features.This heterogeneity has hindered efforts to fully understand the pathology of GC and develop efficient therapeutics.In the past decade,great progress has been made in the study of GC,particularly in molecular subtyping,investigation of the immune microenvironment,and defining the evolutionary path and dynamics.Preclinical mouse models,particularly immunocompetent models that mimic the cellular and molecular features of human GC,in combination with organoid culture and clinical studies,have provided powerful tools for elucidating the molecular and cellular mechanisms underlying GC pathology and immune evasion,and the development of novel therapeutic strategies.Herein,we first briefly introduce current progress and challenges in GC study and subsequently summarize immunocompetent GC mouse models,emphasizing the potential application of genetically engineered mouse models in antitumor immunity and immunotherapy studies.

关 键 词：Gastric cancer HETEROGENEITY mouse model GEMM IMMUNOCOMPETENT 

分 类 号：R735.2[医药卫生—肿瘤]