Quinones from Cordia species from 1972 to 2023:isolation,structural diversity and pharmacological activities  

作　　者：Rostanie Dongmo Zeukang Jarmo-Charles Kalinski Babalwa Tembeni Eleonora D.Goosen Jacqueline Tembu Turibio Tabopda Kuiate Dominique Serge Ngono Bikobo Maurice Tagatsing Fotsing Alex de Théodore Atchadé Xavier Siwe-Noundou 

机构地区：[1]Department of Organic Chemistry,Faculty of Science,University of Yaounde I,PO Box 812,Yaounde,Cameroon [2]Department of Biochemistry and Microbiology,Faculty of Science,Rhodes University,PO Box 94,Makhanda 6140,South Africa [3]Department of Pharmaceutical Sciences,School of Pharmacy,Sefako Makgatho Health Sciences University,Medunsa,PO Box 218,Pretoria 0204,South Africa [4]Division of Pharmaceutical Chemistry,Faculty of Pharmacy,Rhodes University,PO Box 94,Makhanda 6140,South Africa [5]Department of Chemistry,Tshwane University of Technology,Private Bag X680,Pretoria 0001,South Africa

出　　处：《Natural Products and Bioprospecting》2023年第1期93-116,共24页应用天然产物（英文）

基　　金：XS-N kindly acknowledges a National Research Foundation(NRF)Competitive Support for Unrated Researchers(CSUR)grant,Reference Number:SRUG2203291031.

摘　　要：Plants of the genus Cordia(Boraginaceae family)are widely distributed in the tropical regions of America,Africa,and Asia.They are extensively used in folk medicine due to their rich medicinal properties.This review presents a comprehensive analysis of the isolation,structure,biogenesis,and biological properties of quinones from Cordia species reported from 1972 to 2023.Meroterpenoids were identified as the major quinones in most Cordia species and are reported as a chemotaxonomic markers of the Cordia.In addition to this property,quinones are reported to display a wider and broader spectrum of activities,are efficient scaffold in biological activity,compared to other classes of compounds reported in Cordia,hence our focus on the study of quinones reported from Cordia species.About 70 types of quinones have been isolated,while others have been identified by phytochemical screening or gas chromatography.Although the biosynthesis of quinones from Cordia species is not yet fully understood,previous reports suggest that they may be derived from geranyl pyrophosphate and an aromatic precursor unit,followed by oxidative cyclization of the allylic methyl group.Studies have demonstrated that quinones from this genus exhibit antifungal,larvicidal,antileishmanial,anti-inflammatory,antibiofilm,antimycobacterial,antioxidant,antimalarial,neuroinhibitory,and hemolytic activities.In addition,they have been shown to exhibit remarkable cytotoxic effects against several cancer cell lines which is likely related to their ability to inhibit electron transport as well as oxidative phosphorylation,and generate reactive oxygen species(ROS).Their biological activities indicate potential utility in the development of new drugs,especially as active components in drug-carrier systems,against a broad spectrum of pathogens and ailments.

关 键 词：CORDIA BORAGINACEAE QUINONES MEROTERPENOIDS BIOGENESIS Pharmacological activities 

分 类 号：O62[理学—有机化学]