Early-onset and later-onset cancer:trends,risk factors,and prevention in Northern China  

作　　者：Tong Liu Chen-An Liu Qing-Song Zhang Qi Zhang Yi-Ming Wang Meng-Meng Song Shi-Qi Lin Li Deng Shou-Ling Wu Han-Ping Shi 

机构地区：[1]Department of Gastrointestinal Surgery,Department of Clinical Nutrition,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China [2]National Clinical Research Center for Geriatric Diseases,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [3]Key Laboratory of Cancer FSMP for State Market Regulation,Beijing 100038,China [4]Laboratory for Clinical Medicine,Capital Medical University,Beijing 100038,China [5]Department of General Surgery,Kailuan General Hospital,Tangshan 063000,China [6]Department of Genetics,Yale School of Medicine,New Haven 06510,USA [7]Department of Hepatobiliary Surgery,Kailuan General Hospital,Tangshan 063000,China [8]Cardiovascular Research Institute,University of California,San Francisco 94158,USA [9]Department of Cardiology,Kailuan General Hospital,Tangshan 063000,China

出　　处：《Science China(Life Sciences)》2024年第9期1928-1940,共13页中国科学（生命科学英文版）

基　　金：supported by the National Key Research and Development Program of China(2022YFC2009600,2022YFC2009601)to Dr.Hanping Shi;The Jiangxi Province Science Foundation for Youths(20161BAB215187)to Li Deng。

摘　　要：The characteristics of early-onset(onset age<50 years)and later-onset(onset age≥50 years)cancers differ significantly.Identifying novel risk factors for both types of cancer is crucial for increasing awareness of cancer prevention and for reducing its burden.This study aimed to analyze the trends in incidence and risk factors for early-onset and late-onset cancers.We conducted a prospective study by drawing data from the Kailuan Study.This study included 6,741 participants with cancer(624 with early-onset cancer and 6,117 with later-onset cancer)and 6,780 matched controls among the 186,249 participants who underwent Kailuan health examinations from 2006 to 2019.The primary outcomes were cancer incidence rates,and associated risk factors for early-and later-onset cancer.Weighted Cox regression was used to calculate hazard ratios and 95% confidence intervals of each exposure factor for early-and later-onset cancer by cancer type.Populationattributable risk proportions were used to estimate the number of cases that could be prevented by eliminating a risk factor from the population.Except for liver cancer,incidence rates for nearly all types of cancer increased during the study period.Smoking,alcohol consumption,lipid metabolism disorders,hypertension,diabetes mellitus,fatty liver,and inflammation were associated with a significantly increased risk of cancer at multiple sites,but risk factors for cancer incidence differed by site.Smoking,alcohol consumption,inflammation,and hypertension were the major contributors to preventable cancer.The incidence of several different types of cancer,including earlyonset cancer,is increasing in northeastern China.Differences in risk factors between early-onset and later-onset malignancies may contribute to the divergence in the observed changes in incidence trends between these two specific types of cancer.

关 键 词：CANCER EARLY-ONSET later-onset trend risk factor PREVENTION 

分 类 号：R73-31[医药卫生—肿瘤]