Tetramethylpyrazine and paeoniflorin combination(TMP-PF)alleviates atherosclerosis progress by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway  

作　　者：Rong Yuan Qiqi Xin Weili Shi Yu Miao Zhengchuan Zhu Yahui Yuan Ying Chen Xiaoning Chen Sean Xiao Leng Keji Chen Weihong Cong 

机构地区：[1]Cardiovascular Diseases Laboratory,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China [2]National Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China [3]School of Health Economics and Management,Nanjing University of Chinese Medicine,Nanjing 210023,China [4]Department of Otolaryngology,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China [5]Division of Geriatric Medicine and Gerontology,Department of Medicine,Johns Hopkins University School of Medicine,Baltimore 21224,United States

出　　处：《Food Science and Human Wellness》2024年第5期2642-2652,共11页食品科学与人类健康（英文）

基　　金：supported by Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ11-061,ZZ14-YQ-007);the National Natural Science Foundation of China(82004193);CACMS Innovation Fund(CI 2021A00914);Irma and Paul Milstein Program for Senior Health of Milstein Medical Asian American Partnership Foundation。

摘　　要：Atherosclerosis remains a great threat to human health worldwide.Previous studies found that tetramethylpyrazine(TMP)and paeonifl orin(PF)combination(TMP-PF)exerts anti-atherosclerotic effects in vitro.However,whether TMP-PF improves atherosclerosis in vivo needs further exploration.The present study aims to assess the anti-atherosclerotic properties of TMP-PF in ApoE^(-/-)mice and explore the related molecule mechanisms.Results showed that TMP and high-dose TMP-PF decreased serum triglyceride and low-density lipoprotein cholesterol levels,suppressed vascular endothelial growth factor receptor 2(VEGFR2)and nuclear receptor subfamily 4 group A member 1(NR4A1)expression in aortic tissues,inhibited plaque angiogenesis,reduced plaque areas,and alleviated atherosclerosis in ApoE^(-/-)mice.Also,TMP-PF exhibited a better modulation effect than TMP or PF alone.However,NR4A1 agonist abolished the anti-atherosclerotic effects of TMP-PF.In conclusion,TMP-PF was first found to alleviate atherosclerosis progression by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway,indicating that TMP-PF had a positive effect on reducing hyperlipemia and attenuating atherosclerosis development.

关 键 词：ATHEROSCLEROSIS HYPERLIPEMIA ANGIOGENESIS Plaque stability Chinese medicine TETRAMETHYLPYRAZINE PAEONIFLORIN 

分 类 号：R285.5[医药卫生—中药学]