益生菌缓解高尿酸血症:研究现状、作用机制及面临的挑战  

Probiotics in Alleviating Hyperuricemia:Research Status,Mechanism of Action and Challenges

作　　者：杨新如 唐甲越 曾小群[1] 吴振[1] 杜启伟 涂茂林 YANG Xinru;TANG Jiayue;ZENG Xiaoqun;WU Zhen;DU Qiwei;TU Maolin(College of Food Science and Engineering,Ningbo University,Ningbo 315800,China)

机构地区：[1]宁波大学食品科学与工程学院,浙江宁波315800

出　　处：《食品工业科技》2024年第20期415-425,共11页Science and Technology of Food Industry

基　　金：浙江省自然科学基金项目(LQ23C200005);宁波大学科研启动项目(ZX2022000432)。

摘　　要：高尿酸血症(Hyperuricemia,HUA)是一种由嘌呤代谢障碍所引起的,以血液中尿酸过量为特征的慢性代谢性疾病。研究表明,常规的临床治疗方法存在一定的局限性,而益生菌缓解高尿酸血症具有经济有效、毒副作用小、安全性相对较高的特点。本文主要阐述了益生菌缓解高尿酸血症的作用机制:修复肠道屏障、调节肠道微生物群;抑制黄嘌呤氧化酶的活性;加快尿酸排泄;促进嘌呤降解或代谢。益生菌在改善高尿酸血症方面具有广阔的应用前景,是未来缓解和辅助治疗高尿酸血症的重要手段。本文对高尿酸血症、益生菌缓解高尿酸血症的研究现状、作用机制及面临的挑战进行了全面地综述,以期为开发可以缓解高尿酸血症的相关益生菌制剂和营养食品及高尿酸血症的临床治疗提供理论基础和新思路。Hyperuricemia(HUA)is a chronic metabolic disease,characterized by excessive uric acid in the blood,caused by purine metabolism disorders.Studies show that conventional clinical treatment methods have certain limitations,while probiotics have the characteristics of economical and effectiveness,with few toxic side effects,and relatively high safety for alleviating hyperuricemia.This review mainly elaborates the mechanisms of probiotics in alleviating hyperuricemia,involving repairing the intestinal barrier and regulating the gut microbiota,inhibiting the activity of xanthine oxidase,Accelerating uric acid excretion and promoting the degradation or metabolism of purine.Probiotics have broad application prospects in improving hyperuricemia,and which will be an important mean for alleviating and adjuvanting hyperuricemia in the future.This paper comprehensive reviews the research status,mechanism of action,as well as challenges of probiotics in alleviating hyperuricemia,in order to provide a theoretical basis and new ideas for the development of the related probiotic preparations and nutritional foods that can alleviate hyperuricemia,as well as clinical treatment of hyperuricemia.

关 键 词：高尿酸血症 益生菌 尿酸 肠道微生物群 嘌呤 

分 类 号：TS201.4[轻工技术与工程—食品科学]