Regulations of m^(6)A and other RNA modifications and their roles in cancer  

作　　者：Xin-Hui Chen Kun-Xiong Guo Jing Li Shu-Hui Xu Huifang Zhu Guang-Rong Yan 

机构地区：[1]Biomedicine Research Center,Guangdong Provincial Key Laboratory of Major Obstetric Disease,Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology,State Key Laboratory of Respiratory Disease,the Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,510150,China

出　　处：《Frontiers of Medicine》2024年第4期622-648,共27页医学前沿（英文版）

基　　金：supported by National Natural Science Foundation of China(Nos.82125029,82073106,82341016);Science and Technology Projects in Guangzhou(Nos.2023A03J0390,202201020101,202201020124).

摘　　要：RNA modification is an essential component of the epitranscriptome,regulating RNA metabolism and cellular functions.Several types of RNA modifications have been identified to date;they include N^(6)-methyladenosine(m^(6)A),N^(1)-methyladenosine(m1A),5-methylcytosine(m5C),N^(7)-methylguanosine(m^(7)G),N^(6),2′-O-dimethyladenosine(m^(6)Am),N4-acetylcytidine(ac^(4)C),etc.RNA modifications,mediated by regulators including writers,erasers,and readers,are associated with carcinogenesis,tumor microenvironment,metabolic reprogramming,immunosuppression,immunotherapy,chemotherapy,etc.A novel perspective indicates that regulatory subunits and post-translational modifications(PTMs)are involved in the regulation of writer,eraser,and reader functions in mediating RNA modifications,tumorigenesis,and anticancer therapy.In this review,we summarize the advances made in the knowledge of different RNA modifications(especially m^(6)A)and focus on RNA modification regulators with functions modulated by a series of factors in cancer,including regulatory subunits(proteins,noncoding RNA or peptides encoded by long noncoding RNA)and PTMs(acetylation,SUMOylation,lactylation,phosphorylation,etc.).We also delineate the relationship between RNA modification regulator functions and carcinogenesis or cancer progression.Additionally,inhibitors that target RNA modification regulators for anticancer therapy and their synergistic effect combined with immunotherapy or chemotherapy are discussed.

关 键 词：RNA modification WRITERS erasers READERS regulatory subunits PTMS CANCER 

分 类 号：R73[医药卫生—肿瘤]