具有降糖活性N-取代1-脱氧野尻霉素衍生物的研究进展  

Research progress in 1⁃deoxynojirimycin derivatives with hypoglycemic activity

作　　者：闫恳 李光耀 文峻 张辉兰 黄鹏 黄和平 YAN Ken;LI Guang-yao;WEN Jun;ZHANG Hui-lan;HUANG Peng;HUANG He-ping(School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China;Anhui Provincial Key Laboratory of Research and Development of Traditional Chinese Medicines,Hefei 230012,China)

机构地区：[1]安徽中医药大学药学院,合肥230012 [2]中药研究与开发安徽省重点实验室,合肥230012

出　　处：《中国新药杂志》2024年第17期1778-1786,共9页Chinese Journal of New Drugs

基　　金：安徽省高校自然科学研究重点资助项目(KJ2020A-0422);亳州职业技术学院第一批“医疗服务与保障能力提升补助”专项课题资助项目(YLFW2310)。

摘　　要：1-脱氧野尻霉素是一种多羟基哌啶类生物碱,具有多种药理活性。作为α-葡萄糖苷酶的强抑制剂,其在降血糖领域被广泛研究。目前研究主要集中于通过药物化学拼合原理、结构杂合、提升价态等方式对1-脱氧野尻霉素进行结构修饰,以期提升其专一性,增加其降糖活性。本文主要对近年来具有降糖活性的N-取代1-脱氧野尻霉素衍生物研究进展进行总结与分析,为其在降糖方面的应用提供参考。1⁃deoxynojirimycin is a polyhydroxypyridine alkaloid with various pharmacological activities.As a strong inhibitor ofα⁃glucosidase,it has been widely studied in the field of hypoglycemia.In order to enhance its specificity and further increase its hypoglycemic activity,researchers mainly modify the structure of 1⁃deoxynojirimycin through principles of assembly,structural hybridization,and valence state enhancement.This article mainly summarized N⁃substituted 1⁃deoxynojirimycin derivatives with hypoglycemic activity in recent years,providing reference for their application in hypoglycemic therapy.

关 键 词：1-脱氧野尻霉素 Α-葡萄糖苷酶 降血糖 研究进展 

分 类 号：R914[医药卫生—药物化学]