食药用菌多糖调控胃肠道功能的研究进展  

Research Progress on the Regulation of Gastrointestinal Function by Polysaccharides from Edible and Medicinal Mushroom

作　　者：刘建辉 戴燚 岳玉玲 刘拓宇 杨文建 陆欢[2] LIU Jianhui;DAI Yi;YUE Yuling;LIU Tuoyu;YANG Wenjian;LU Huan(Collaborative Innovation Center for Modern Grain Circulation and Safety,Jiangsu Province Engineering Research Center of Edible Fungus Preservation and Intensive Processing,College of Food Science and Engineering,Nanjing University of Finance and Economics,Nanjing 210023,China;Key Laboratory of Edible Fungi Resources and Utilization(South),Ministry of Agricultural and Rural Affairs,National Engineering Research Center of Edible Fungi,Institute of Edible Fungi,Shanghai Academy of Agricultural Sciences,Shanghai 201403,China)

机构地区：[1]南京财经大学食品科学与工程学院,江苏省现代粮食流通与安全协同创新中心,江苏省食用菌保鲜与深加工工程研究中心,江苏南京210023 [2]上海市农业科学院食用菌研究所,农业农村部南方食用菌资源利用重点实验室,囯家食用菌工程技术研究中心,上海201403

出　　处：《食品科学》2024年第20期270-279,共10页Food Science

基　　金：国家自然科学基金青年科学基金项目(32202033)。

摘　　要：胃肠道是人体最大的、与外界相通的器官,具有消化食物、运输和吸收营养成分的作用。胃肠黏膜屏障可以通过物理、化学、生物和免疫屏障作用保障胃肠道功能,其损伤会导致慢性炎症或急、慢性疾病。多糖为食药用菌中的主要生物活性物质,可用于多种胃肠道相关疾病的辅助治疗。本文综述了食药用菌多糖在清除胃幽门螺旋杆菌、保护胃黏膜损伤及胃溃疡和抗胃癌功效等调控胃部健康方面的作用与机制,总结了食药用菌多糖在维持肠道稳态与调节肠道菌群、改善炎症性肠病、抑制结肠癌等调控肠道健康方面的作用,分析了食药用菌多糖调控胃肠道功能的作用机制,可为食药用菌多糖促进胃肠道健康及相关机制的深入研究提供参考。The gastrointestinal tract is the largest organ in the human body that communicates with the outside world.It has the functions of digesting food and transporting and absorbing nutrients.The gastrointestinal mucosal barrier secures gastrointestinal function through physical,chemical,biological,and immunologic barriers,and its damage can lead to chronic inflammation or acute and chronic diseases.Polysaccharides are one of the major bioactive substances in edible and medicinal mushroom and can be used as an auxiliary treatment for a variety of gastrointestinal diseases.This article reviews the roles of polysaccharides from edible and medicinal mushroom in regulating gastric health such as eliminating gastric Helicobacter pylori,protecting against gastric mucosal damage and gastric ulcer,and fighting against gastric cancer,summarizes the roles of polysaccharides from edible and medicinal mushroom in maintaining intestinal homeostasis and regulating the intestinal microbiota,alleviating inflammatory bowel disease and inhibiting colon cancer,and analyzes the regulatory mechanisms of polysaccharides from edible and medicinal mushroom on gastrointestinal function.We expect that this review will provide a reference for in-depth research on the promoting effect and mechanism of polysaccharides from edible and medicinal mushroom on gastrointestinal health.

关 键 词：食药用菌 多糖 胃肠道功能 胃肠黏膜屏障 

分 类 号：TS201.4[轻工技术与工程—食品科学]