高频重复经颅磁刺激联合氟伏沙明改善青少年抑郁症患者抑郁情绪、冲动性及自伤水平的效果探讨  

Effect of high-frequency repetitive transcranial magnetic stimulation combined with fluvoxamine treatment on improving depression,impulsivity,and self-injury levels in adolescent patients with depression

作　　者：徐鹏昊 王艳 毛丽彦 徐裕 Xu Penghao;Wang Yan;Mao Liyan;Xu Yu(Department of Psychiatry,The Third Hospital of Quzhou,Quzhou 324000,Zhejiang Province,China)

机构地区：[1]衢州市第三医院精神科,衢州324000

出　　处：《中国基层医药》2024年第9期1368-1372,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省衢州市科技攻关项目(2023K189)。

摘　　要：目的探讨高频重复经颅磁刺激联合氟伏沙明改善青少年抑郁症患者抑郁情绪、冲动性及自伤水平的效果。方法前瞻性收集2022年1月至2023年11月在衢州市第三医院精神科接受治疗的青少年抑郁症患者124例,按照随机数字表法进行分组,对照组和观察组各62例,对照组接受单纯氟伏沙明治疗,观察组接受高频重复经颅磁刺激联合氟伏沙明治疗。比较两组疗效以及汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分、Barratt冲动量表(BIS-Ⅱ)修订版评分及非自杀性自伤行为功能评估量表(NSSI-AT)修订版评分。结果观察组有效率[90.32%(56/62)]高于对照组治疗[(72.58%(45/62)],差异有统计学意义(χ^(2)=6.46,P<0.05);治疗后,观察组HAMD及HAMA评分[(12.08±1.97)分、(11.58±1.59)分]均低于对照组[(16.42±2.33)分][(14.42±1.94)分],差异均有统计学意义(t=-8.28,-18.61,均P<0.05);治疗后,观察组BIS-Ⅱ修订版评分及NSSI-AT修订版评分均低于对照组[(28.25±3.91)分、(9.23±2.12)分],差异均有统计学意义(t=5.42,9.44,均P<0.05)。结论高频重复经颅磁刺激联合氟伏沙明能够显著改善青少年抑郁症患者抑郁情绪,降低患者的冲动性及自伤水平。Objective To investigate the effect of high-frequency repetitive transcranial magnetic stimulation combined with fluvoxamine treatment on improving depression,impulsivity,and self-injury levels in adolescent patients with depression.Methods A total of 124 adolescent patients with depression who received treatment at the Department of Psychiatry,The Third Hospital of Quzhou,China from January 2022 to November 2023 were included in this study.The patients were randomly divided into a control group and an observation group,with 62 patients per group,using the random number table method.Patients in the control group received treatment with fluvoxamine,while patients in the observation group underwent high-frequency repetitive transcranial magnetic stimulation and treatment with fluvoxamine.Clinical efficacy and the scores of the Hamilton Depression Scale,Hamilton Anxiety Scale,the Barratt Impulsiveness Scale-ll revised version,and the Non-Suicidal Self-Injury Assessment Tool revised version were compared between the two groups.Results The total response rate in the observation group was 90.32%(56/62),which was significantly higher than that in the control group[72.58%(45/62),χ^(2)=6.46,P<0.05].After treatment,scores of the Hamilton Depression Scale and Hamilton Anxiety Scale in the observation group were(12.08±1.97)points and(11.58±1.59)points,respectively,which were significantly lower than those in the control group[(16.42±2.33)points,(14.42±1.94)points,t=-8.28,-18.61,both P<0.05].After treatment,the scores of the Barratt Impulsiveness Scale-ll revised version and Non-Suicidal Self-Injury Assessment Tool revised version in the observation group were significantly lower than those in the control group[(28.25±3.91)points,(9.23±2.12)points,t=5.42,9.44,both P<0.05].Conclusion High-frequency repetitive transcranial magnetic stimulation combined with fluvoxamine treatment can significantly reduce depressive symptoms,impulsivity,and self-injury levels in adolescent patients with depression.

关 键 词：抑郁症 经颅磁刺激 青少年 冲动行为 自我伤害行为 氟伏沙明 

分 类 号：R749.4[医药卫生—神经病学与精神病学]