Nuance of inward rectifying potassium(Kir)channel dysfunctions in neurodegenerative diseases  

作　　者：Benjamin Garland Linlin Ma 

机构地区：[1]Griffith Institute for Drug Discovery&School of Environment and Science,Griffith University,Nathan,Brisbane,QLD,Australia

出　　处：《Neural Regeneration Research》2024年第6期1195-1196,共2页中国神经再生研究（英文版）

基　　金：supported by Michael J Fox Foundation (US);Shake It Up Australia Foundation Grant (Australia)[Grant MJFF-021285] to LM

摘　　要：Neurodegenerative disorders are highly prevalent and diverse in nature.Their manifestation largely depends on the cell types involved,with aberrant inflammatory episodes progressively inducing a constellation of phenotypes that are classified into specific diseases based on their neuropathological traits.The two most prevalent neurodegenerative diseases worldwide,Alzheimer’s disease(AD)and Parkinson’s disease(PD),for example,share notable similarities,yet they differ in terms of the specific cell types lost within the central nervous system(CNS).The significant and progressive loss of cortical and certain subcortical neurons in various regions is a major defining trait of AD.In contrast,the specific loss of dopaminergic neurons(DA)within the substantial nigra pars compacta(SNpc)is sufficient to cause motor symptoms associated with PD.Another devastating condition arising from neurodegeneration within the CNS,amyotrophic lateral sclerosis(ALS),results in the progressive death of upper and lower motor neurons.This degeneration originates in oligodendrocytes,whose defective myelination abilities lead to the denervation of the anterior horn,aggravating motor neuron death.

关 键 词：diseases DEGENERATIVE DEGENERATION 

分 类 号：R741[医药卫生—神经病学与精神病学]