Role of Exosomal Modulation of Macrophages in Liver Fibrosis  

作　　者：Bin Fan He Xie Qi Tan Qingyuan Li Tao Gong Baoren He Yujia Li Limin Chen 

机构地区：[1]Institute of Blood Transfusion(IBT),Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC),Chengdu,Sichuan,China [2]The Hospital of Xidian Group,Xi’an,Shaanxi,China [3]Department of Clinical Medicine,North Sichuan Medical College,Nanchong,Sichuan,China [4]The Joint Laboratory of Transfusion-Transmitted Diseases(TTDs)between Institute of Blood Transfusion(IBT),Chinese Academy of Medical Sciences(CAMS)and Nanning Blood Center,Nanning,Guangxi,China

出　　处：《Journal of Clinical and Translational Hepatology》2024年第2期201-209,共9页临床与转化肝病杂志（英文版）

基　　金：CAMS Initiative for Innovative Medicine:CAMS-2021-I2M-1-060;National Key Research and Development Program of China:2018YFE0107500;Science and Technology Partnership Program,Ministry of Science and Technology of China:KY201904011;Qin Chuang Yuan recruited highlevel innovation and entrepreneurship talents project of Science and Technology Department of Shaanxi Province:QCYRCXM-2022-56;Foreign Expert Service Project of Science and Technology Department of Shaanxi Province:2023 WGZJ-YB-39;Medical Research project of Xi’an Science and Technology Bureau:22YXYJ0120.

摘　　要：Exosomes are 60–120 nm diameter double-membrane lipid organelles discharged by cells.Various studies have shown that exosomes exert multiple functions in both physical and diseased processes,such as intercellular information exchange,immune response,and disease progression.Repeated chronic injury to the liver often leads to inflammation and liver fibrosis(LF),a disorder that,if unchecked,may progress to cirrhosis,liver failure,portal hypertension,and even hepatocellular carcinoma.As an essential component of host innate immunity against pathogen invasion,macrophages play an important role in modulating inflammation homeostasis by finely tuning the polarization process of macrophages into either M1 or M2 subtypes in response to different microenvironments.As a critical contributor to the inflammation process,macrophages also play a complex and instrumental function in the progression of LF.This review focuses on recent advancements in the role of macrophage-associated exosomes implicated in LF,including macrophage-released exosomes and macrophage-targeted exosomes.In addition,the progress made in exosomebased antifibrotic therapy by in vivo and in vitro studies is also highlighted.

关 键 词：EXOSOME Macrophage Liver fibrosis HEPATOCYTE Mesenchymal stem cell Hepatic stellate cell 

分 类 号：R575[医药卫生—消化系统]