Thallium’s Threat to Aquatic Life:Stage-Specific Toxicity in Zebrafish Embryos and Larvae  

作　　者：Jian Liu Guizhen Yan Zihui Huo Yucong Mo Yuting Wen Weizhen Liu Hongyu Zhou Bing Yan Zhang Lin 

机构地区：[1]School of Environment and Energy,Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Recycling,South China University of Technology,Guangzhou,Guangdong 510006,China [2]Institute of Environmental Research at Greater Bay Area,Key Laboratory for Water Quality and Conservation of the Pearl River Delta,Ministry of Education,Guangzhou University,Guangzhou,Guangdong 510006,China [3]School of Metallurgy and Environment,Central South University,Changsha 410083,China

出　　处：《Environment & Health》2024年第3期114-125,共12页环境与健康（英文）

基　　金：supported by the National Natural Science Foundation of China(22076033,22022602,and 22036002);the National Key Research and Development Program of China(2019YFA0210400);the Pearl River Young Talents Program of Guangdong Province(2017GC010269);the introduced innovative R&D team project under“The Pearl River Talent Recruitment Program”of Guangdong Province(2019ZT08L387);Major program Natural Science Foundation of Hunan Province of China(2021JC0001).

摘　　要：The escalating frequency of thallium(Tl)contamination incidents amplifies its environmental risk.However,the potential risk of Tl to aquatic organisms,especially across varying developmental stages,remains poorly understood.In this study,we employed zebrafish as a representative model organism and exposed zebrafish embryos and larvae at distinct developmental periods(specifically,6 h postfertilization(hpf)and 72 hpf)to low concentrations of Tl(I)(0.25 and 0.50 mg/L).The exposure was performed for a short duration of 24 h,followed by a 96 h depuration period.Our results revealed that Tl(I)exerted disparate biological effects on zebrafish at different developmental stages.Embryos exhibited negligible uptake of Tl(I),whereas larvae showed a significant accumulation of Tl(I)and struggled with its rapid elimination.Notably,Tl(I)was able to permeate the blood-brain barrier,thereby posing a risk to the nervous system.Transcriptomic analysis indicated that Tl(I)triggered distinct toxicological pathways in embryos and larvae.It mainly interfered with metabolic processes in embryos,while in larvae,it mainly disrupted intracellular ion homeostasis,both consequently provoking neurotoxicity.This emphasizes that the multifaceted nature of Tl(I)toxicity depends on the developmental stages of the organism.This study clearly shows that the bioeffects of Tl are intricately related to the developmental stage of zebrafish,offering a valuable perspective for the pollutant toxicity assessment.

关 键 词：THALLIUM ZEBRAFISH Uptake DEPURATION NEUROTOXICITY 

分 类 号：X171.5[环境科学与工程—环境科学]