Tumor microenvironment squeezes out the juice from Tcells  

作　　者：Romane Thouenon Gregory Verdeil 

机构地区：[1]Department of Oncology UNIL CHUv,University of Lausanne,Vaud,Switzerland [2]Ludwig Institute for Cancer Research,University of Lausanne,Lausanne,Switzerland.

出　　处：《Cell Research》2024年第10期677-678,共2页细胞研究（英文版）

摘　　要：Escaping the immune response is a major prerequisite for tumor to emerge and progress,and many different mechanisms are in place within the tumor microenvironment(TME)to reach this aim,including the induction of CD8^(+)T cell exhaustion.In a recent publication in Cell,Zhang and colleagues showed that biomechanical stress occurring in the TME enforces CD8^(+)T cell exhaustion through the expression of the transcription factor Osr2 that acts as an epigeneticregulator.First identified in chronic infection,exhausted CD8^(+)T cells express multiple inhibitory receptors,have reduced effector functions,and are not able to efficiently control pathogens or tumors.1The main inducer of exhaustion is the continuous triggering of the T cell receptor(TCR),2 but several factors present in the tumor microenvironment(TME)such as metabolite deprivation,high pH or hypoxia could further participate in the induction and maintenance of this program in a cancer-specific manner.3 The exhaustion program is established through the expression of several transcription factors(TFs)such as TOX.

关 键 词：MICROENVIRONMENT TUMOR INFECTION 

分 类 号：R730[医药卫生—肿瘤]