Unraveling the routes to distant metastases in colorectal cancer:Tumor deposits and lymph node metastases as the gateway  

作　　者：Nelleke Pietronella Maria Brouwer Ayse Selcen Oguz Erdogan Shannon van Vliet Natasja Rutgers Nikki Knijn Gesina van Lijnschoten Jessica Juliana Tan Johannes Hendrik Willem de Wilt Niek Hugen Gina Brown Femke Simmer Iris Dionne Nagtegaal 

机构地区：[1]Department of Pathology,Radboud University Medical Center,Nijmegen,Gelderland,The Netherlands [2]Department of Pathology,PathologyDNA,Arnhem,Gelderland,The Netherlands [3]Department of Pathology,Eurofins/Laboratoria voor Pathologie en Medische Microbiologie Nederland,Eindhoven,Noord-Brabant,The Netherlands [4]GI Cancer Imaging Research Unit,The Royal Marsden Hospital,Sutton,London,United Kingdom [5]Department of Surgery,Radboud University Medical Center,Nijmegen,Gelderland,The Netherlands [6]Department of Surgery,Netherlands Cancer Institute,Amsterdam,Noord-Holland,The Netherlands [7]Department of Surgery,Rijnstate Hospital,Arnhem,Gelderland,The Netherlands [8]Imperial College London Hammersmith Campus,London,London,United Kingdom

出　　处：《Cancer Communications》2024年第10期1209-1213,共5页癌症通讯（英文）

基　　金：supported by the Dutch Cancer Society(KUN 2019-12640).

摘　　要：Currently,lymph node metastases(LNM)are seen as the gateway to distant metastases in CRC and play a crucial role in the Tumor Node Metastasis(TNM)staging system[1,2].Tumor deposits(TD)have been identified as another histological feature with a strong prognostic impact but are currently only deemed clinically relevant in the absence of LNM[2,3].TD are clusters of tumor cells in the fat surrounding the bowel and are often associated with nerves,vessels and lymphatic tissue,giving the cancer cells access to multiple routes of spread[4].

关 键 词：METASTASES CANCER GATEWAY 

分 类 号：R735.37[医药卫生—肿瘤]