一氧化氮在孤独症中作用及调控机制进展  

Progress on the role and regulatory mechanism of nitric oxide in autism

作　　者：白璐 张月美 向往 肖亚倩 黄胜 朱红敏[6] 王军[1,2,3,4,5] BAI Lu;ZHANG Yuemei;XIANG Wang;XIAO Yaqian;HUANG Sheng;ZHU Hongmin;WANG Jun(The Ministry of Industrial Fermentation Jointly Established a Collaborative Innovation Center,Hubei University of Technology,Wuhan 430068;Cell Regulation and Molecular Pharmacy Innovation Introduction Base(“111 Base”),Hubei University of Technology,Wuhan 430068;Institute for Diagnosis and Intervention of Autism and Depression,Hubei University of Technology,Wuhan 430068;International Joint Research Center for Health and Precision Medicine and Nutrition,Hubei University of Technology,Wuhan 430068;Department of Bioengineering and Food,Hubei University of Technology,Wuhan 430068;Department of Rehabilitation Medicine,Wuhan Children's Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei University of Technology,Wuhan 430019,China)

机构地区：[1]湖北工业大学工业发酵省部共建协同创新中心,湖北武汉430068 [2]湖北工业大学细胞调控与分子药物学科创新引智基地(“111基地”),湖北武汉430068 [3]湖北工业大学孤独症抑郁症诊断与干预研究所,湖北武汉430068 [4]湖北工业大学大健康与精准医药营养国际联合研究中心,湖北武汉430068 [5]湖北工业大学生物工程与食品学院,湖北武汉430068 [6]华中科技大学同济医学院附属武汉儿童医院康复医学科,湖北武汉430019

出　　处：《生物技术》2024年第5期665-670,共6页Biotechnology

基　　金：国家自然科学基金项目(82061138005);湖北省教育厅创新团队项目(T2020009)。

摘　　要：一氧化氮(NO)是一种重要的生物信号分子,在人体生理病理中发挥重要作用。孤独症(ASD)是一种复杂的神经发育障碍疾病,目前病因不明。在ASD患者中发现NO水平异常,但NO在ASD病因中发挥怎样的作用尚不清楚。该文综述了NO生理功能,通过ASD的多种致病风险因素探究NO如何参与调控ASD发病机制,从NO对ASD发病机制的调控角度为ASD诊断和治疗提供理论依据。Nitric oxide(NO)is an important biological signaling molecule,which plays an important role in human physiology and pathology.Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with unknown etiology.At present,abnormal levels of NO have been found in ASD patients,but what role NO plays in the etiology of ASD is still unclear.This article focuses on the physiological function of NO,and explores how NO is involved in the regulation of ASD pathogenesis through a variety of pathogenic risk factors of ASD.Through mechanism exploration,it provides new ideas for the etiology of ASD and new targets for the treatment of ASD.The regulation of NO on the pathogenesis of ASD provides theoretical support for the diagnosis and treatment of ASD.

关 键 词：孤独症 一氧化氮 基因突变 环境毒素暴露 神经发育异常 

分 类 号：R749.94[医药卫生—神经病学与精神病学]