Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration  

作　　者：Prajakta Deshpande Anuradha Venkatakrishnan Chimata Amit Singh 

机构地区：[1]Department of Biology,University of Dayton,Dayton,OH,USA [2]Premedical Program,University of Dayton,Dayton,OH,USA [3]Center for Tissue Regeneration and Engineering at Dayton(TREND),University of Dayton,Dayton,OH,USA [4]Integrative Science and Engineering Center,University of Dayton,Dayton,OH,USA [5]Center for Genomic Advocacy(TCGA),Indiana State University,Terre Haute,IN,USA

出　　处：《Neural Regeneration Research》2025年第10期2862-2871,共10页中国神经再生研究（英文版）

基　　金：supported by 1RO1EY032959-01 and RO1 supplement from NIH,Schuellein Chair Endowment Fund and STEM Catalyst Grant from the University of Dayton(to AS).

摘　　要：Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivotal to basic cellular processes.Close to 80%-90%of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and localization.In this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in diseases.Furthermore,we have focused on N-acetyltransferase 9 and its role in microtubule stability.We have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative diseases.We have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.

关 键 词：acetyl-coenzyme A Alzheimer’s disease animal models cell death DROSOPHILA eye human disease c-Jun N-terminal kinase signaling N-Acetyltransferases N-acetyltransferase 9 NEURODEGENERATION 

分 类 号：R363[医药卫生—病理学]