铬(Ⅲ)参与调控机体糖脂代谢的作用机制研究进展  

Research Progress on the Mechanism of Chromium(Ⅲ)in Regulating Glucose and Lipid Metabolism

作　　者：李倩 袁勇敢 张燕青 宋莲军[1,2,3] 程永霞 黄现青 LI Qian;YUAN Yonggan;ZHANG Yanqing;SONG Lianjun;CHENG Yongxia;HUANG Xianqing(School of Food science and Technology,Henan Agricultural University,Zhengzhou 450002,China;Henan Province Engineering Research Center for Food Safety Control of Processing and Circulation,Zhengzhou 450002,China;Zhengzhou Key Laboratory of Soybean Processing,Zhengzhou 450002,China)

机构地区：[1]河南农业大学食品科学技术学院,河南郑州450002 [2]河南省食品加工与流通安全控制工程技术研究中心,河南郑州450002 [3]郑州市大豆深加工重点实验室,河南郑州450002

出　　处：《食品工业科技》2024年第22期397-405,共9页Science and Technology of Food Industry

基　　金：河南农业大学科技创新基金资助项目(KJCX2021A19);河南省研究生联合培养基地项目(YJS2022JD16);河南省高校科技创新团队支持计划资助(23IRTSTHN023)。

摘　　要：铬(Ⅲ)是人体必需的微量元素之一,与胰岛素的合成、分泌及其在体内的含量有着密切的联系,能够参与调节机体的糖脂代谢,具有降糖、降脂等多种重要的生理作用。糖脂代谢异常是许多慢性病的病因,发病机制复杂。铬(Ⅲ)与机体糖脂代谢有关,因此本文对铬(Ⅲ)的安全性以及对糖脂代谢影响的相关研究进行了综合分析,阐述了铬(Ⅲ)通过调节AMPK/GLUT-4、PI3K/Akt信号通路增强胰岛素敏感性,促进葡萄糖吸收及糖原合成,改善胰岛素抵抗;通过调节SREBP-1C、ACC1、CD36表达改善脂质代谢的作用机制,旨在为铬(Ⅲ)防治糖尿病和肥胖等代谢类疾病提供理论基础,使其能够进一步应用于食品工业中。Chromium(III)is an essential trace element for the human body.It modulates the synthesis,secretion,and content of insulin in the body.In addition to participating in the regulation of glucose and lipid metabolism,it performs various important physiological functions,including the reduction of glucose and lipid levels.Glucose and lipid metabolism disorders are the cause of many chronic diseases and have a complex pathogenesis.Research shows that chromium(III)is related to glucose and lipid metabolism.Therefore,this study performes a meta-analysis of studies related to the safety of chromium(III)and its influence on glucose and lipid metabolism and elucidated the mechanisms.Chromium(III)can enhance insulin sensitivity,promote glucose absorption and glycogen synthesis and improve insulin resistance by regulating AMPK/GLUT-4 and PI3K/Akt signaling pathways.And it also can improve lipid metabolism by regulating the expression of SREBP-1C,ACC1 and CD36.The article would provide a theoretical basis for the use of chromium(III)toward the prevention and treatment of metabolic diseases,such as diabetes mellitus and obesity,so that it could be further applied in the food industry.

关 键 词：铬 脂代谢 糖代谢 糖尿病 作用机制 

分 类 号：TS201.4[轻工技术与工程—食品科学]