Future perspectives:advances in bone/cartilage organoid technology and clinical potential  

作　　者：Jingtao Huang Aikang Li Rongji Liang Xiaohao Wu Shicheng Jia Jiayou Chen Zilu Jiao Canfeng Li Xintao Zhang Jianjing Lin 

机构地区：[1]Department of Sports Medicine and Rehabilitation,Peking University Shenzhen Hospital,Shenzhen,Gunagdong Province,China [2]Department of Clinical Medicine,Shantou University Medical College,Shantou,Gunagdong Province,China [3]Department of Bone&Joint Surgery,Peking University Shenzhen Hospital,Shenzhen,Gunagdong Province,China [4]Immunology and Rheumatology,School of Medicine,Stanford University,Palo Alto,CA,USA

出　　处：《Biomaterials Translational》2024年第4期425-443,共19页生物材料转化电子杂志（英文）

基　　金：supported by National Natural Science Foundation of China(No.82272568);Sanming Project of Medicine in Shenzhen(No.SZSM202211019);Guangdong Basic and Applied Basic Research Foundation(Nos.2023A1515220019&2022A1515220056);“Merro”Young Physician Innovation and Development Project(No.GSKQNJJ-2023-004);Peking University Shenzhen Hospital Scientific Research Fund(No.KYQD2023297).

摘　　要：Bone and cartilage tissues are essential for movement and structure,yet diseases like osteoarthritis affect millions.Traditional therapies have limitations,necessitating innovative approaches.Organoid technology,leveraging stem cells’regenerative potential,offers a novel platform for disease modelling and therapy.This review focuses on advancements in bone/cartilage organoid technology,highlighting the role of stem cells,biomaterials,and external factors in organoid development.We discuss the implications of these organoids for regenerative medicine,disease research,and personalised treatment strategies,presenting organoids as a promising avenue for enhancing cartilage repair and bone regeneration.Bone/cartilage organoids will play a greater role in the treatment of bone/cartilage diseases in the future,and promote the progress of biological tissue engineering.

关 键 词：BIOMATERIALS BONE CARTILAGE ORGANOIDS stem cells tissue engineering 

分 类 号：R318.1[医药卫生—生物医学工程]