靶向肠道微生态的炎症性肠病治疗进展  

Research progress of intestinal microecology as therapeutic targetforinflammatoryboweldisease

作　　者：邢孟泽 何真[1,2,3] Xing Mengze;He Zhen(Department of General Surgery(Colorectal Surgery),the Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China;Biomedical Innovation Center,the Sixth Affiliated Hospital,Sun Yat-sen UUniversity,Guangzhou 510655,China;Key Laboratory of Human Microbiome and Chronic Diseases(Sun Yat-sen University),Ministry of Education,Guangzhou 510655,China)

机构地区：[1]中山大学附属第六医院普通外科(结直肠外科),广州510655 [2]广州市黄埔区中六生物医学创新研究院,广州510655 [3]人体微生态与老年慢性疾病教育部重点实验室,广州510655

出　　处：《中华炎性肠病杂志（中英文）》2024年第5期350-357,共8页Chinese Journal of Inflammatory Bowel Diseases

摘　　要：炎症性肠病(IBD)是一种慢性炎性疾病,以药物治疗为主。但目前的免疫调节治疗存在有效率低、安全性未明的问题,亟需寻找新的辅助治疗或替代疗法。肠道微生态作为新的治疗靶点在IBD的发生发展中占据重要地位,有望在IBD下一代治疗中发挥关键作用。目前已有粪菌移植、益生菌疗法、益生元疗法、饮食疗法、噬菌体疗法等用于调控IBD肠道微生态。本文总结肠道微生态调控治疗IBD的研究进展。Inflammatory bowel disease(IBD)is a chronic inflammatory disease,which is primarily treated with medication.However,the insufficient efficacy and safety risk of current immunoregulatory therapies mean that finding new adjuvant or alternative therapies is urgently needed.As a new therapeutic target,intestinal microecology occupies an important position in the occurrence and development of IBD and is expected to play a pivotal role in the next generation of IBD therapy.Currently,fecal microbiota transplantation,probiotic therapy,prebiotic therapy,dietary therapy and bacteriophage therapy have been used to regulate the intestinal microecology of IBD.This article reviews the research progress of intestinal microecology regulation in the treatment of IBD.

关 键 词：炎症性肠病 肠道微生态 粪菌移植 益生菌 益生元 饮食 噬菌体 

分 类 号：R574[医药卫生—消化系统]