Pre-metastatic niche: formation, characteristics and therapeutic implication  

作　　者：Yuhang Wang Jiachi Jia Fuqi Wang Yingshuai Fang Yabing Yang Quanbo Zhou Weitang Yuan Xiaoming Gu Junhong Hu Shuaixi Yang 

机构地区：[1]Department of Colorectal Surgery,The First Affiliated Hospital of Zhengzhou University,1 East Jianshe Road,Zhengzhou,450000,China [2]College of Medicine,Zhengzhou University,Zhengzhou,450001,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第10期4512-4542,共31页信号转导与靶向治疗（英文）

基　　金：Henan Medical Science and Technology Research Plan(No.LHG120230294,to S.Y.);The China Postdoctoral Science Foundation(No.2023M743201,to S.Y.);National funded postdoctoral researcher program(No.GZB20230671,to S.Y.);Provincial and Ministry Co-constructed Key Projects of Henan Medical Science and Technology(No.SBGJ202102121,to J.H.).

摘　　要：Distant metastasis is a primary cause of mortality and contributes to poor surgical outcomes in cancer patients. Before the development of organ-specific metastasis, the formation of a pre-metastatic niche is pivotal in promoting the spread of cancer cells. This review delves into the intricate landscape of the pre-metastatic niche, focusing on the roles of tumor-derived secreted factors, extracellular vesicles, and circulating tumor cells in shaping the metastatic niche. The discussion encompasses cellular elements such as macrophages, neutrophils, bone marrow-derived suppressive cells, and T/B cells, in addition to molecular factors like secreted substances from tumors and extracellular vesicles, within the framework of pre-metastatic niche formation. Insights into the temporal mechanisms of pre-metastatic niche formation such as epithelial-mesenchymal transition, immunosuppression, extracellular matrix remodeling, metabolic reprogramming, vascular permeability and angiogenesis are provided. Furthermore, the landscape of pre-metastatic niche in different metastatic organs like lymph nodes, lungs, liver, brain, and bones is elucidated. Therapeutic approaches targeting the cellular and molecular components of pre-metastatic niche, as well as interventions targeting signaling pathways such as the TGF-β, VEGF, and MET pathways, are highlighted. This review aims to enhance our understanding of pre-metastatic niche dynamics and provide insights for developing effective therapeutic strategies to combat tumor metastasis.

关 键 词：METASTATIC metastasis THERAPEUTIC 

分 类 号：R730[医药卫生—肿瘤]