An NIR-propelled janus nanomotor with enhanced ROS-scavenging,immunomodulating and biofilm-eradicating capacity for periodontitis treatment  

作　　者：Xuan Bai Wenan Peng Ying Tang Ziming Wang Jingmei Guo Fangfang Song Hongye Yang Cui Huang 

机构地区：[1]State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School&Hospital of Stomatology,Wuhan University,Wuhan,430079,China

出　　处：《Bioactive Materials》2024年第11期271-292,共22页生物活性材料（英文）

基　　金：Fundamental Research Funds for the Central Universities(2042022kf1206);National Natural Science Foundation of China(82271010).

摘　　要：Periodontitis is an inflammatory disease caused by bacterial biofilms,which leads to the destruction of periodontal tissue.Current treatments,such as mechanical cleaning and antibiotics,struggle to effectively address the persistent biofilms,inflammation,and tissue damage.A new approach involves developing a Janus nanomotor(J-CeM@Au)by coating cerium dioxide-doped mesoporous silica(CeM)with gold nanoparticles(AuNPs).This nanomotor exhibits thermophoretic motion when exposed to near-infrared(NIR)laser light due to the temperature gradient produced by the photothermal effects of asymmetrically distributed AuNPs.The NIR laser provides the energy for propulsion and activates the nanomotor's antibacterial properties,allowing it to penetrate biofilms and kill bacteria.Additionally,the nanomotor's ability to scavenge reactive oxygen species(ROS)can modulate the immune response and create a regenerative environment,promoting the healing of periodontal tissue.Overall,this multifunctional nanomotor offers a promising new approach for treating periodontitis by simultaneously addressing biofilm management and immune modulation with autonomous movement.

关 键 词：PERIODONTITIS NANOMOTORS Photothermal therapy Reactive oxygen species Biofilm eradication OSTEOGENESIS 

分 类 号：R781.42[医药卫生—口腔医学]